Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K14 | Q99558 | 11/20 | 0.47 |
| ▸ | JAK1 | P23458 | 5/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.37 |
| ▸ | JAK3 | P52333 | 4/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.36 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.36 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650494 | 0.92 | MAP3K14 (0.46) | MAP3K14JAK1JAK2JAK3TBK1 | |
| SCHEMBL22650489 | 0.84 | MAP3K14 (0.48) | MAP3K14IKBKETBK1 | |
| SCHEMBL22650849 | 0.74 | CDK1 (0.47) | JAK1JAK2JAK3 | |
| SCHEMBL22650848 | 0.73 | CDK1 (0.49) | JAK1JAK2JAK3 | |
| SCHEMBL22650936 | 0.72 | IKBKE (0.48) | MAP3K14JAK1JAK2JAK3IKBKE | |
| SCHEMBL22650851 | 0.72 | IKBKB (0.56) | — | |
| SCHEMBL22650921 | 0.72 | MTOR (0.49) | — | |
| SCHEMBL22650796 | 0.70 | CDK2 (0.44) | JAK2JAK3 | |
| SCHEMBL22650923 | 0.70 | MAPK8 (0.54) | JAK2 | |
| SCHEMBL22650920 | 0.69 | CDK2 (0.54) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |