Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKE | Q14164 | 12/20 | 0.48 |
| ▸ | TBK1 | Q9UHD2 | 12/20 | 0.48 |
| ▸ | MYLK4 | Q86YV6 | 2/20 | 0.43 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.41 |
| ▸ | TYK2 | P29597 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | BTK | Q06187 | 2/20 | 0.40 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.40 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22650489 | 0.87 | MAP3K14 (0.48) | IKBKETBK1MAP3K14ACVR1 | |
| SCHEMBL22650526 | 0.75 | MAP4K1 (0.44) | MYLK4STK17AJAK2JAK3 | |
| SCHEMBL22650422 | 0.74 | CDK1 (0.41) | MYLK4STK17AJAK2JAK1JAK3 | |
| SCHEMBL22650919 | 0.74 | CDK2 (0.54) | MYLK4STK17AJAK2JAK3 | |
| SCHEMBL22650923 | 0.74 | MAPK8 (0.54) | MYLK4STK17AJAK2ACVR1 | |
| SCHEMBL22650918 | 0.74 | DKK1 (0.57) | JAK2 | |
| SCHEMBL22650849 | 0.74 | CDK1 (0.47) | MYLK4STK17AJAK2JAK1JAK3 | |
| SCHEMBL22650707 | 0.73 | JAK2 (0.39) | MYLK4STK17AJAK2JAK3BTK | |
| SCHEMBL22650920 | 0.73 | CDK2 (0.54) | MYLK4STK17AJAK2JAK1TYK2 | |
| SCHEMBL22650595 | 0.72 | PRKCA (0.40) | JAK2JAK3MAP3K14ACVR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020224568-A1 | CDK INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2020-11-12 | — | — | WO | disclosed |