SCHEMBL22650558

SCHEMBL22650558

COc1nc(-c2nc(Nc3ccc(N4CCN(CCF)CC4)cn3)ncc2F)cc2c1ncn2C(C)C

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CDK6 Q00534 17/20 0.47
CDK4 P11802 13/20 0.47
CSF1R P07333 1/20 0.47
CCND3 P30281 12/20 0.46
CDK1 P06493 11/20 0.46
CCNA2 P20248 11/20 0.46
CCND1 P24385 9/20 0.46
CDK2 P24941 9/20 0.46
CCNE2 O96020 7/20 0.46
PIM1 P11309 1/20 0.44
CDK5 Q00535 1/20 0.44
CCNT1 O60563 1/20 0.43
CCNE1 P24864 1/20 0.43
CDK7 P50613 1/20 0.43
CDK9 P50750 1/20 0.43
CCNH P51946 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650629 0.89 CDK6 (0.41) CDK6CDK4CSF1RCCND3CDK1
SCHEMBL22650431 0.86 CDK6 (0.53) CDK6CDK4CSF1RCCND3CDK1
SCHEMBL22650865 0.85 CDK4 (0.55) CDK6CDK4CSF1RCCND3CDK1
SCHEMBL22650547 0.83 CDK6 (0.43) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL22650956 0.82 CDK6 (0.59) CDK6CDK4CSF1RCCND3CDK1
SCHEMBL22650949 0.81 CDK6 (0.45) CDK6CDK4CSF1RCCND3CDK1
SCHEMBL22650723 0.80 CDK4 (0.48) CDK6CDK4CSF1RCCND3CDK1
SCHEMBL22650636 0.79 CDK4 (0.64) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL22650560 0.78 CCND1 (0.36) CDK6CDK4CCND3CDK1CCNA2
SCHEMBL22650859 0.75 CDK4 (0.51) CDK6CDK4CSF1RCCND3CDK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed