SCHEMBL22650771

SCHEMBL22650771

CC1(N)CCN(c2ccc(Nc3nccc(-c4cc(F)c5c(c4)C4(CCCC4)CO5)n3)nc2)C(=O)C1

nearest known ligand 0.43

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CDK6 Q00534 20/20 0.43
CCND3 P30281 15/20 0.43
CDK4 P11802 15/20 0.41
CDK1 P06493 10/20 0.39
CCNA2 P20248 9/20 0.39
CCNE2 O96020 7/20 0.38
CDK2 P24941 7/20 0.38
CCND1 P24385 7/20 0.38
PIM1 P11309 2/20 0.37
CCNE1 P24864 1/20 0.37
CCNT1 O60563 1/20 0.36
CDK7 P50613 1/20 0.36
CDK9 P50750 1/20 0.36
CCNH P51946 1/20 0.36
MNAT1 P51948 1/20 0.36
CDK5 Q00535 1/20 0.36
CDK5R1 Q15078 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22650772 0.93 CDK6 (0.46) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650492 0.79 CDK6 (0.58) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650509 0.79 CDK6 (0.48) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650773 0.78 CDK4 (0.45) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650507 0.77 CDK6 (0.45) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL29462408 0.74 DYRK2 (0.47) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650497 0.74 DYRK2 (0.47) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650755 0.72 CDK4 (0.42) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650705 0.72 CDK6 (0.39) CDK6CCND3CDK4CDK1CCNA2
SCHEMBL22650576 0.71 CDK6 (0.38) CDK6CCND3CDK4CDK1CCNA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020224568-A1 CDK INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2020-11-12 WO disclosed