Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | BCL9 | O00512 | 1/20 | 0.45 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27508148 | 0.80 | CA1 (0.47) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL2265246 | 0.78 | IDO1 (0.50) | HTR2ACA1CA2ALDH1A1TSHR | |
| SCHEMBL6377945 | 0.78 | HTR2A (0.49) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL6377951 | 0.78 | HTR2A (0.49) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL30579722 | 0.77 | BCL9 (0.51) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL10875695 | 0.74 | BCL9 (0.49) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL10876891 | 0.74 | CYP19A1 (0.46) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL27624600 | 0.74 | CYP19A1 (0.46) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL5044150 | 0.74 | BCL9 (0.49) | HTR2ABCL9CTNNB1CA1CA2 | |
| SCHEMBL21633908 | 0.74 | MEN1 (0.51) | HTR2ABCL9CTNNB1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8569536-B2 | C-nitroso-derived nitroxyl donors | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2013-10-29 | — | — | US | disclosed |
| US-20130040919-A1 | C-NITROSO-DERIVED NITROXYL DONORS | KING S BRUCE (US) | 2013-02-14 | — | — | US | disclosed |
| US-8269034-B2 | C-nitroso-derived nitroxyl donors | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2012-09-18 | — | — | US | disclosed |
| US-20110263674-A1 | C-NITROSO-DERIVED NITROXYL DONORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2011-10-27 | — | — | US | disclosed |
| US-7989652-B2 | C-nitroso-derived nitroxyl donors | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2011-08-02 | — | — | US | disclosed |
| US-20100173970-A1 | C-NITROSO-DERIVED NITROXYL DONORS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-07-08 | — | — | US | disclosed |
| US-7696373-B2 | C-nitroso-derived nitroxyl donors | WAKE FOREST UNIVERSITY HEALTH SCIENCES (US) | 2010-04-13 | — | — | US | disclosed |
| US-20090137668-A1 | C-NITROSO-DERIVED NITROXYL DONORS | WAKE FOREST UNIVERSITY HEALTH SCIENCES | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263674-A1 | C-NITROSO-DERIVED NITROXYL DONORS | NOS1, NOS2, NOS3 | HTR2A 2011/4885BCL9 2016/4885CTNNB1 2241/4885 |
| US-20130040919-A1 | C-NITROSO-DERIVED NITROXYL DONORS | NOS1, NOS2, NOS3 | HTR2A 2011/4885BCL9 2016/4885CTNNB1 2241/4885 |
| US-20100173970-A1 | C-NITROSO-DERIVED NITROXYL DONORS | NOS1, NOS2, NOS3 | HTR2A 2011/4885BCL9 2016/4885CTNNB1 2241/4885 |
| US-20090137668-A1 | C-NITROSO-DERIVED NITROXYL DONORS | NOS1, NOS2, NOS3 | HTR2A 2348/4885BCL9 1946/4885CTNNB1 2086/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.