Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTR1D | P28221 | 1/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.43 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1454985 | 0.82 | KCNA3 (0.52) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| SCHEMBL9503356 | 0.79 | KCNA3 (0.58) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| SCHEMBL195569 | 0.79 | TDP1 (0.64) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| SCHEMBL11224430 | 0.79 | KCNA3 (0.48) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| SCHEMBL28352207 | 0.78 | KCNA3 (0.47) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| Ammonia Solution, Strong SCHEMBL8909905 | 0.78 | TDP1 (0.62) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| SCHEMBL21985397 | 0.77 | SIGMAR1 (0.51) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| SCHEMBL11758866 | 0.77 | LTA4H (0.58) | KCNA3SIGMAR1LTA4HTDP1 | |
| SCHEMBL21096683 | 0.76 | KCNA3 (0.54) | KCNA3SIGMAR1HTR1BLMNAHTR1D | |
| SCHEMBL6698794 | 0.76 | KCNA3 (0.54) | KCNA3SIGMAR1HTR1BLMNAHTR1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738084-A1 | G1T38 SUPERIOR DOSAGE REGIMES | G1 Therapeutics, Inc. (US) | 2020-11-18 | — | — | EP | disclosed |