Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.88 |
| ▸ | HMGCR | P04035 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ACLY | P53396 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | SLC13A5 | Q86YT5 | 4/20 | 0.41 |
| ▸ | CPT2 | P23786 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL4441599 | 1.00 | ALDH1A1 (0.88) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL16671164 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5473892 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL215570 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL36149 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL36150 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL117285 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL3275086 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5473889 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A | |
| Citric Acid SCHEMBL5987710 | 0.97 | ALDH1A1 (0.94) | ALDH1A1HMGCRCHRM1TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 650 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051475-B2 | Rheology modified pretreatment compositions and associated methods of use | PPG INDUSTRIES OHIO, INC. (US) | 2015-06-09 | — | — | US | claimed |
| US-20140356617-A1 | RHEOLOGY MODIFIED PRETREATMENT COMPOSITIONS AND ASSOCIATED METHODS OF USE | PPG IND OHIO INC (US) | 2014-12-04 | — | — | US | claimed |
| US-8852357-B2 | Rheology modified pretreatment compositions and associated methods of use | PPG INDUSTRIES OHIO, INC (US) | 2014-10-07 | — | — | US | claimed |
| WO-2013052195-A2 | RHEOLOGY MODIFIED PRETREATMENT COMPOSITIONS AND ASSOCIATED METHODS OF USE | PPG INDUSTRIES OHIO, INC. (US) | 2013-04-11 | — | — | WO | claimed |
| US-20130084466-A1 | RHEOLOGY MODIFIED PRETREATMENT COMPOSITIONS AND ASSOCIATED METHODS OF USE | PPG INDUSTRIES OHIO, INC. (US) | 2013-04-04 | — | — | US | claimed |
| US-7370959-B2 | Ink-jet recording sheet and method for preparing the same | FUJIFILM CORPORATION (JP) | 2008-05-13 | — | — | US | claimed |
| CN-100345693-C | Ink-jet recording sheet | FUJI PHOTO FILM CO LTD (JP) | 2007-10-31 | — | — | CN | claimed |
| US-20060088671-A1 | Ink-jet recording sheet and method for preparing the same | FUJI PHOTO FILM CO., LTD. | 2006-04-27 | — | — | US | claimed |
| US-6813884-B2 | Method of treating diesel exhaust gases | FORD GLOBAL TECHNOLOGIES, LLC | 2004-11-09 | — | — | US | claimed |
| US-6576587-B2 | High surface area lean NOx catalyst | DELPHI TECHNOLOGIES, INC. | 2003-06-10 | — | — | US | claimed |
| EP-0837049-B1 | A process for preparing monomers | ROHM & HAAS (US) | 2002-07-31 | — | — | EP | claimed |
| EP-0871801-B1 | ELECTROPLATING PROCESSES COMPOSITIONS AND DEPOSITS | ENTHONE OMI INC (US) | 2002-07-17 | — | — | EP | claimed |
| WO-2000078671-A1 | A METHOD OF MAKING PARTICLES OF METAL OXIDE HAVING A LARGE CRYSTALLINE PHASE | BATTELLE MEMORIAL INSTITUTE (US) | 2000-12-28 | — | — | WO | claimed |
| US-5856611-A | Zirconium catalyzed transesterification process for preparing synthetic wax monomers | ROHM AND HAAS COMPANY (US) | 1999-01-05 | — | — | US | claimed |
| CN-1200774-A | Electroplating method, composition and deposit | ENTHONE OMI INC (US) | 1998-12-02 | — | — | CN | claimed |
| EP-0871801-A1 | ELECTROPLATING PROCESSES COMPOSITIONS AND DEPOSITS | ENTHONE-OMI, Inc. (US) | 1998-10-21 | — | — | EP | claimed |
| US-5789350-A | Compositions and processes for treating hydrocarbon-bearing formations | PHILLIPS PETROLEUM COMPANY (US) | 1998-08-04 | — | — | US | claimed |
| WO-1997017482-A1 | ELECTROPLATING PROCESSES COMPOSITIONS AND DEPOSITS | ENTHONE-OMI INC. (US) | 1997-05-15 | — | — | WO | claimed |
| EP-0324382-A2 | Zirconium (III) salts as cure co-catalysts for nonwoven binders comprising acrylamidoglycolic acid | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1989-07-19 | — | — | EP | claimed |
| US-4844970-A | CROSSLINKABLE ANIONIC POLYMER | AIR PRODUCTS AND CHEMICALS, INC. (US) | 1989-07-04 | — | — | US | claimed |