Sugi Predict

Sugi Predict / Compounds / SCHEMBL587010

SCHEMBL587010

SCHEMBL587010

O=C(Cl)c1cnccc1Cl

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ROCK2 O75116 1/20 0.58
▸ ROCK1 Q13464 1/20 0.58
▸ TDP1 Q9NUW8 2/20 0.42
▸ SIRT3 Q9NTG7 1/20 0.42
▸ CYP11B2 P19099 1/20 0.41
▸ JAK2 O60674 2/20 0.41
▸ TYK2 P29597 2/20 0.41
▸ GAA P10253 1/20 0.40
▸ ALDH1A1 P00352 2/20 0.39
▸ KDM4C Q9H3R0 2/20 0.39
▸ KDM4E B2RXH2 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ KDM6B O15054 1/20 0.39
▸ KDM4A O75164 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ KDM4D Q6B0I6 1/20 0.39
▸ L3MBTL1 Q9Y468 1/20 0.39
▸ JAK1 P23458 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30465597 1.00 ROCK2 (0.58) ROCK2ROCK1TDP1SIRT3CYP11B2
Hydrochloric Acid SCHEMBL2432397 0.98 ROCK2 (0.56) ROCK2ROCK1TDP1SIRT3CYP11B2
SCHEMBL7533 0.83 ROCK2 (0.58) ROCK2ROCK1TDP1SIRT3GAA
SCHEMBL29574646 0.83 ROCK2 (0.58) ROCK2ROCK1TDP1SIRT3GAA
SCHEMBL15514423 0.83 ROCK2 (0.58) ROCK2ROCK1TDP1SIRT3CYP11B2
SCHEMBL1027774 0.83 GAA (0.45) ROCK2ROCK1TDP1SIRT3CYP11B2
SCHEMBL2265522 0.82 KDM4C (0.47) ROCK2ROCK1TDP1SIRT3GAA
SCHEMBL651312 0.81 SIRT3 (0.60) ROCK2ROCK1TDP1SIRT3GAA
Hydrochloric Acid SCHEMBL17143441 0.81 ROCK2 (0.56) ROCK2ROCK1TDP1SIRT3GAA
Hydrochloric Acid SCHEMBL2841145 0.81 GAA (0.43) ROCK2ROCK1TDP1SIRT3CYP11B2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 142 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112851547-A Fluorenoxime ester compound, preparation method thereof and photosensitive resin composition 常州强力先端电子材料有限公司 2021-05-28 — — CN claimed
CN-106946770-B High-activity imido phenylacetate compound and preparation method and application thereof 中国农业大学 2020-05-05 — — CN claimed
CN-108299418-A A kind of synthetic method of the thiazolyl nicotinamide compound of antiallergy and asthma 刘双伟 2018-07-20 — — CN claimed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 — — EP claimed
US-12595245-B2 Inhibitors of MET kinase CELYN THERAPEUTICS, INC. (US) 2026-04-07 — — US disclosed
US-20250263379-A1 NOVEL PYRIDINIUM COMPOUND KAO CORPORATION (JP) 2025-08-21 — — US disclosed
EP-4509495-A1 NOVEL PYRIDINIUM COMPOUND Kao Corporation (JP) 2025-02-19 — — EP disclosed
WO-2024199395-A1 OXIME ESTER PHOTOINITIATOR, PHOTOCURABLE RESIN COMPOSITION AND USE 常州强力先端电子材料有限公司 2024-10-03 — — WO disclosed
CN-118742542-A Inhibitors of MET kinase 金耐特生物制药公司 2024-10-01 — — CN disclosed
US-20240067626-A1 INHIBITORS OF MET KINASE CELYN THERAPEUTICS, INC. 2024-02-29 — — US disclosed
US-11753395-B2 Inhibitors of MET kinase KINNATE BIOPHARMA INC. (US) 2023-09-12 — — US disclosed
US-20230219929-A1 INHIBITORS OF MET KINASE CELYN THERAPEUTICS, INC. 2023-07-13 — — US disclosed
WO-1995006033-A1 2-OXIMINO-2-PYRIDYL ACETIC ACID DERIVATIVES AS ANTI-PARASITIC AGENTS (FUNGICIDES) BAYER AKTIENGESELLSCHAFT (DE) 1995-03-02 — — WO disclosed
US-5300672-A For water systems, plant diseases ROHM AND HAAS COMPANY (US) 1994-04-05 — — US disclosed
US-5166390-A Bactericides ROHM AND HAAS COMPANY (US) 1992-11-24 — — US disclosed
EP-0440329-A1 S-substituted carbonyl substituted betathioacrylamide biocides and fungicides ROHM AND HAAS COMPANY (US) 1991-08-07 — — EP disclosed
US-RE32975-E FUNGICIDES, BACTERICIDES, FEED ADDITIVES BAYER AKTIENGESELLSCHAFT (DE) 1989-07-04 — — US disclosed
EP-0004279-B1 PROCESS FOR THE PREPARATION OF 4-PYRIDONE-3-CARBOXYLIC ACIDS, 1-CYCLOPROPYL-4-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES AND MEDICINES CONTAINING THEM BAYER AG (DE) 1982-12-29 — — EP disclosed
US-4284629-A ANIMAL GROWTH REGULATORS BAYER AKTIENGESELLSCHAFT (DE) 1981-08-18 — — US disclosed
EP-0004279-A1 Process for the preparation of 4-pyridone-3-carboxylic acids, 1-cyclopropyl-4-pyridone-3-carboxylic acid derivatives and medicines containing them BAYER AG (DE) 1979-10-03 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12595245-B2 Inhibitors of MET kinase MET, ABL1, ERBB2 ROCK2 578/4885ROCK1 770/4885TDP1 3802/4885
US-20230219929-A1 INHIBITORS OF MET KINASE MET, RET, MERTK ROCK2 358/4885ROCK1 401/4885TDP1 4225/4885
US-11753395-B2 Inhibitors of MET kinase MET, RET, MERTK ROCK2 358/4885ROCK1 401/4885TDP1 4225/4885
US-20250263379-A1 NOVEL PYRIDINIUM COMPOUND PYM1, F11, CHRM1 ROCK2 2112/4885ROCK1 1401/4885TDP1 2559/4885
US-20240067626-A1 INHIBITORS OF MET KINASE MET, RET, MERTK ROCK2 358/4885ROCK1 401/4885TDP1 4225/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.