Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 7/20 | 0.42 |
| ▸ | CFTR | P13569 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP7 | P55210 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | IKBKB | O14920 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23130237 | 0.79 | MAPT (0.38) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL25081219 | 0.76 | KDM4E (0.54) | MAPTGAAALDH1A1HSD17B10ALOX15 | |
| SCHEMBL25111828 | 0.74 | ALDH1A1 (0.45) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL8497588 | 0.74 | ALOX15 (0.50) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL12655816 | 0.73 | ALDH1A1 (0.40) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL3233191 | 0.71 | NR4A1 (0.50) | GAAALDH1A1HSD17B10CYP3A4SMN1; SMN2 | |
| SCHEMBL20319418 | 0.71 | ALDH1A1 (0.42) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL2494996 | 0.71 | ALOX15 (0.53) | MAPTGAAALDH1A1HSD17B10CFTR | |
| Anthranilamide SCHEMBL2801971 | 0.70 | HSD17B10 (0.58) | MAPTGAAALDH1A1HSD17B10CFTR | |
| SCHEMBL165079 | 0.70 | MAPT (0.46) | MAPTGAAALDH1A1HSD17B10CFTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3738958-A1 | AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES AS CCR(9) ANTAGONISTS | ChemoCentryx, Inc. (US) | 2020-11-18 | — | — | EP | disclosed |