SCHEMBL22668237

SCHEMBL22668237

CCCc1ccc(OCc2ccc(OC/C(=N\OC)c3ccccc3)c(OC)c2)cc1F

nearest known ligand 0.49

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
FFAR1 O14842 15/20 0.49
PPARD Q03181 6/20 0.41
SLC6A4 P31645 1/20 0.41
MRGPRX4 Q96LA9 1/20 0.39
ABCB1 P08183 1/20 0.39
ABCG2 Q9UNQ0 1/20 0.39
FFAR4 Q5NUL3 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL435340 0.90 FFAR1 (0.53) FFAR1PPARDFFAR4
SCHEMBL435339 0.90 FFAR1 (0.53) FFAR1PPARDFFAR4
SCHEMBL15239688 0.88 FFAR1 (0.49) FFAR1PPARDMRGPRX4FFAR4
SCHEMBL15239689 0.88 FFAR1 (0.49) FFAR1PPARDMRGPRX4FFAR4
SCHEMBL22668477 0.82 FFAR1 (0.46) FFAR1
SCHEMBL434058 0.78 FFAR1 (0.61) FFAR1FFAR4
SCHEMBL434057 0.78 FFAR1 (0.61) FFAR1FFAR4
SCHEMBL22668386 0.77 RAB9A (0.46) FFAR1
SCHEMBL22668429 0.77 FFAR1 (0.42) FFAR1PPARDMRGPRX4
SCHEMBL435519 0.76 FFAR1 (0.54) FFAR1PPARDMRGPRX4FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2595952-B1 AGONISTS OF GPR40 CONNEXIOS LIFE SCIENCES PVT LTD (IN) 2020-11-18 EP disclosed