Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28487170 | 0.91 | HPGD (0.53) | HPGDALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL16597715 | 0.89 | TSHR (0.49) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL22673922 | 0.89 | KMT2A (0.47) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL22673801 | 0.85 | MEN1 (0.53) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL16597967 | 0.84 | PARP10 (0.43) | HPGDALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL28487173 | 0.83 | HPGD (0.47) | HPGDALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL22673848 | 0.83 | MEN1 (0.49) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL22673925 | 0.83 | ATM (0.40) | LMNAALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL22674058 | 0.82 | MEN1 (0.50) | HPGDLMNAALDH1A1MEN1KMT2A | |
| SCHEMBL22674061 | 0.82 | MEN1 (0.50) | HPGDLMNAALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3966204-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | Nenan Normal University (CN) | 2022-03-16 | — | — | EP | disclosed |
| WO-2020228637-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN NORMAL UNIVERSITY (CN) | 2020-11-19 | — | — | WO | disclosed |