Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22673718 | 0.89 | HPGD (0.48) | KMT2AMAPTHTTMEN1ALDH1A1 | |
| SCHEMBL16597946 | 0.88 | PARP10 (0.47) | KMT2AMAPTHTTGPR119MEN1 | |
| SCHEMBL22673933 | 0.87 | NPSR1 (0.46) | KMT2ANPSR1MAPTGPR119ATM | |
| SCHEMBL22673925 | 0.85 | ATM (0.40) | KMT2ANPSR1MAPTHTTGPR119 | |
| SCHEMBL16597967 | 0.84 | PARP10 (0.43) | KMT2AMAPTHTTGPR119MEN1 | |
| SCHEMBL22673801 | 0.83 | MEN1 (0.53) | KMT2ANPSR1MEN1ALDH1A1GAA | |
| SCHEMBL22674061 | 0.82 | MEN1 (0.50) | KMT2ANPSR1MEN1ALDH1A1GAA | |
| SCHEMBL22674058 | 0.82 | MEN1 (0.50) | KMT2ANPSR1MEN1ALDH1A1GAA | |
| SCHEMBL22673848 | 0.82 | MEN1 (0.49) | KMT2ANPSR1MEN1ALDH1A1GAA | |
| SCHEMBL28487170 | 0.80 | HPGD (0.53) | HTTALDH1A1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228637-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN NORMAL UNIVERSITY (CN) | 2020-11-19 | — | — | WO | disclosed |