Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 10/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.41 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22673922 | 0.87 | KMT2A (0.47) | NPSR1MAPTGPR119ATMKMT2A | |
| SCHEMBL22673718 | 0.81 | HPGD (0.48) | MAPTKMT2AMEN1ALDH1A1LMNA | |
| SCHEMBL6705316 | 0.79 | L3MBTL1 (0.51) | NPSR1MAPTGPR119KDM4EPKM | |
| SCHEMBL22673801 | 0.78 | MEN1 (0.53) | NPSR1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL22674061 | 0.78 | MEN1 (0.50) | NPSR1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL22674058 | 0.78 | MEN1 (0.50) | NPSR1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL22673848 | 0.77 | MEN1 (0.49) | NPSR1KDM4EKMT2AMEN1ALDH1A1 | |
| SCHEMBL22673925 | 0.77 | ATM (0.40) | NPSR1MAPTGPR119ATMKMT2A | |
| SCHEMBL785988 | 0.77 | HPGD (0.48) | GPR119KDM4EPKMKMT2AMEN1 | |
| SCHEMBL8040438 | 0.77 | NAMPT (0.54) | NPSR1MAPTGPR119KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12291516-B2 | Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's tyrosine kinase inhibitors | HENAN ZHIWEI BIOMEDICINE CO., LTD. (CN) | 2025-05-06 | — | — | US | disclosed |
| EP-3966204-B1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN ZHIWEI BIOMEDICINE CO LTD (CN) | 2024-11-27 | — | — | EP | disclosed |
| CN-111909133-B | Substituted 1-amino-1H-imidazole-5-carboxamides as inhibitors of brunauer tyrosine kinase | 河南知微生物医药有限公司 | 2023-07-14 | — | — | CN | disclosed |
| US-20220259181-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN ZHIWEI BIOMEDICINE CO., LTD. (CN) | 2022-08-18 | — | — | US | disclosed |
| WO-2020228637-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | HENAN NORMAL UNIVERSITY (CN) | 2020-11-19 | — | — | WO | disclosed |
| CN-111909133-A | Substituted 1-amino-1H-imidazole-5-carboxamides as brunauer tyrosine kinase inhibitors | 河南师范大学 | 2020-11-10 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220259181-A1 | SUBSTITUTED 1-AMINO-1H-IMIDAZOLE-5-CARBOXAMIDE AS BRUTON'S TYROSINE KINASE INHIBITORS | BTK, SYK, TYK2 | NPSR1 3697/4885MAPT 812/4885GPR119 2721/4885 |
| US-12291516-B2 | Substituted 1-amino-1H-imidazole-5-carboxamide as Bruton's tyrosine kinase inhibitors | BTK, SYK, TYK2 | NPSR1 3697/4885MAPT 812/4885GPR119 2721/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.