Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.32 |
| ▸ | NOS2 | P35228 | 1/20 | 0.32 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.32 |
| ▸ | PDE5A | O76074 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.30 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.30 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19864857 | 0.72 | LIMK1 (0.33) | LIMK1L3MBTL1NOS3NOS2NUDT1 | |
| SCHEMBL19969968 | 0.72 | LIMK1 (0.33) | LIMK1L3MBTL1NOS3NOS2NUDT1 | |
| SCHEMBL7519562 | 0.71 | — | — | |
| SCHEMBL179602 | 0.67 | LIMK1 (0.38) | LIMK1L3MBTL1NOS3NOS2PDE5A | |
| SCHEMBL29512944 | 0.65 | — | — | |
| SCHEMBL3037141 | 0.65 | — | — | |
| SCHEMBL22651230 | 0.65 | ADORA2A (0.33) | LIMK1L3MBTL1LMNA | |
| SCHEMBL2316376 | 0.64 | CHEK1 (0.42) | NOS3NOS2NUDT1LMNACHEK1 | |
| SCHEMBL25016860 | 0.64 | — | — | |
| SCHEMBL21090760 | 0.63 | NUDT1 (0.35) | LIMK1L3MBTL1NOS3NOS2NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |