Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 2/20 | 0.43 |
| ▸ | FEN1 | P39748 | 2/20 | 0.43 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.37 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 2/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22676393 | 0.82 | ALOX5AP (0.46) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL24773521 | 0.80 | ALOX5AP (0.45) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL30306048 | 0.80 | ALOX5AP (0.45) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL25714089 | 0.80 | ALOX5AP (0.45) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL26585989 | 0.80 | ALOX5AP (0.50) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL31129024 | 0.74 | RXRA (0.45) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL22659251 | 0.72 | ALOX5AP (0.39) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL25129367 | 0.72 | ALOX5AP (0.41) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 | |
| SCHEMBL24773007 | 0.71 | ALOX5AP (0.53) | ALOX5APFEN1CYP3A4CYP2D6FGFR1 | |
| SCHEMBL30717991 | 0.71 | ALOX5AP (0.50) | ALOX5APFEN1TRPA1CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4306529-A2 | FGFR INHIBITORS AND METHODS OF USE THEREOF | Relay Therapeutics, Inc. (US) | 2024-01-17 | — | — | EP | disclosed |
| WO-2020231990-A1 | FGFR INHIBITORS AND METHODS OF USE THEREOF | RELAY THERAPEUTICS, INC. (US) | 2020-11-19 | — | — | WO | disclosed |