Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | RXRG | P48443 | 1/20 | 0.49 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CETP | P11597 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22682095 | 0.83 | RXRA (0.49) | RXRARXRBRXRGKDM4CMEN1 | |
| SCHEMBL22681736 | 0.83 | RXRA (0.44) | RXRARXRBRXRGKDM4C | |
| SCHEMBL22682009 | 0.82 | RXRA (0.43) | RXRARXRBRXRGKDM4CMAPT | |
| SCHEMBL17378763 | 0.81 | RXRA (0.46) | RXRARXRBRXRGKDM4CMEN1 | |
| SCHEMBL13569439 | 0.81 | ALDH1A1 (0.43) | RXRARXRBRXRGKDM4CMEN1 | |
| SCHEMBL22682020 | 0.81 | KDM6B (0.45) | RXRARXRBRXRGKDM4CMAPT | |
| SCHEMBL11310810 | 0.80 | TSHR (0.44) | — | |
| SCHEMBL22681849 | 0.79 | CHKA (0.42) | RXRARXRBRXRGKDM4C | |
| SCHEMBL22681645 | 0.79 | RXRA (0.41) | RXRARXRBRXRGKDM4CMEN1 | |
| SCHEMBL22681798 | 0.79 | RXRA (0.43) | RXRARXRBRXRGKDM4CMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3160952-B1 | HISTONE DEMETHYLASE INHIBITORS | CELGENE QUANTICEL RES INC (US) | 2020-12-02 | — | — | EP | disclosed |
| EP-3741749-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-11-25 | — | — | EP | disclosed |
| EP-3738960-A1 | HISTONE DEMETHYLASE INHIBITORS | Celgene Quanticel Research, Inc. (US) | 2020-11-18 | — | — | EP | disclosed |