Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.38 |
| ▸ | BRAF | P15056 | 3/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.38 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.36 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29331748 | 0.86 | KCNH2 (0.41) | KCNH2SCN9AL3MBTL1LMNAMAPT | |
| SCHEMBL30816944 | 0.84 | KCNH2 (0.42) | KCNH2SCN9AL3MBTL1RAB9ASLC6A4 | |
| SCHEMBL23111617 | 0.84 | KCNH2 (0.42) | KCNH2SCN9AL3MBTL1RAB9ASLC6A4 | |
| SCHEMBL25338761 | 0.81 | KMT2A (0.43) | KCNH2SCN9AL3MBTL1LMNAMAPT | |
| SCHEMBL25340189 | 0.78 | KCNH2 (0.41) | KCNH2SCN9ALMNARAB9ALTA4H | |
| SCHEMBL30482536 | 0.78 | KCNH2 (0.41) | KCNH2SCN9ALMNARAB9ALTA4H | |
| SCHEMBL17179355 | 0.78 | MEN1 (0.47) | KCNH2SCN9AMAPTKMT2A | |
| SCHEMBL7456975 | 0.77 | FGFR2 (0.48) | KCNH2LMNAMAPTSLC6A4HTR2A | |
| SCHEMBL25429249 | 0.73 | KCNH2 (0.44) | KCNH2SCN9ALMNAMAPTKDR | |
| SCHEMBL19510904 | 0.72 | LMNA (0.46) | KCNH2SCN9ALMNAMAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220213074-A1 | ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME | H. LUNDBECK A/S (DK) | 2022-07-07 | — | — | US | disclosed |
| CN-113939290-A | ABHD12 inhibitors and methods of making and using the same | H.隆德贝克有限公司 | 2022-01-14 | — | — | CN | disclosed |
| WO-2020232153-A1 | ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME | LUNDBECK LA JOLLA RESEARCH CENTER, INC. (US) | 2020-11-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213074-A1 | ABHD12 INHIBITORS AND METHODS OF MAKING AND USING SAME | ABHD12, SAMHD1, ABHD11 | KCNH2 4671/4885SCN9A 4720/4885L3MBTL1 862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.