Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
| ▸ | CLK2 | P49760 | 1/20 | 0.33 |
| ▸ | HIPK1 | Q86Z02 | 1/20 | 0.33 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.33 |
| ▸ | HIPK3 | Q9H422 | 1/20 | 0.33 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.33 |
| ▸ | APP | P05067 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | MINK1 | Q8N4C8 | 1/20 | 0.33 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 2/20 | 0.32 |
| ▸ | AKT1 | P31749 | 1/20 | 0.32 |
| ▸ | AKT2 | P31751 | 1/20 | 0.32 |
| ▸ | TKT | P29401 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22684799 | 0.71 | IDO1 (0.39) | APPKCNH2 | |
| SCHEMBL22685173 | 0.69 | IDO1 (0.42) | MAP4K4 | |
| SCHEMBL24448654 | 0.68 | TRPV4 (0.47) | — | |
| SCHEMBL22685235 | 0.68 | CLK1 (0.35) | CLK1CLK2HIPK1HIPK2HIPK3 | |
| SCHEMBL25222544 | 0.67 | MAP4K4 (0.50) | MAP4K4FEN1SYK | |
| SCHEMBL30112165 | 0.67 | MAP4K4 (0.50) | MAP4K4FEN1SYK | |
| SCHEMBL25195525 | 0.67 | PDK2 (0.41) | MAP4K4FEN1 | |
| SCHEMBL30042674 | 0.67 | PDK2 (0.41) | MAP4K4FEN1 | |
| SCHEMBL898882 | 0.66 | HSP90AA1 (0.38) | KCNH2PIK3CAPI4KBPTGS2TKT | |
| SCHEMBL29745069 | 0.66 | HSP90AA1 (0.38) | KCNH2PIK3CAPI4KBPTGS2TKT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020228823-A1 | NOVEL AMIDE COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2020-11-19 | — | — | WO | disclosed |