SCHEMBL22688804

SCHEMBL22688804

C=C(C)COc1cc(F)ccc1C(C)=O

nearest known ligand 0.47

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAOB P27338 6/20 0.47
MAOA P21397 3/20 0.47
ALDH1A1 P00352 4/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
HTT P42858 1/20 0.44
PKM P14618 1/20 0.42
MAPT P10636 3/20 0.41
KMT2A Q03164 3/20 0.41
KDM4E B2RXH2 1/20 0.41
LMNA P02545 1/20 0.41
FFAR4 Q5NUL3 1/20 0.40
PTGDR2 Q9Y5Y4 2/20 0.40
CYP3A4 P08684 1/20 0.40
TSHR P16473 1/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
AKR1A1 P14550 1/20 0.39
AKR1B1 P15121 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30845513 1.00 MAOB (0.47) MAOBMAOAALDH1A1SMN1; SMN2HTT
SCHEMBL13603939 0.87 MAOB (0.44) MAOBMAOAALDH1A1SMN1; SMN2HTT
SCHEMBL4271221 0.82 CYP3A4 (0.61) MAOBMAOAALDH1A1SMN1; SMN2MAPT
SCHEMBL30628273 0.82 CYP3A4 (0.61) MAOBMAOAALDH1A1SMN1; SMN2MAPT
SCHEMBL22688733 0.81 CYP3A4 (0.46) MAOBMAOAALDH1A1SMN1; SMN2HTT
SCHEMBL12051096 0.81 ABCB1 (0.46) MAOBMAOAALDH1A1SMN1; SMN2MAPT
SCHEMBL22688702 0.80 ALDH1A1 (0.38) MAOBMAOAALDH1A1SMN1; SMN2HTT
SCHEMBL4126877 0.80 FLT3 (0.46) MAOBMAOAALDH1A1SMN1; SMN2MAPT
SCHEMBL18329451 0.80 MAOB (0.43) MAOBMAOAALDH1A1SMN1; SMN2HTT
SCHEMBL13637553 0.79 LMNA (0.52) MAOBMAOAALDH1A1SMN1; SMN2HTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113727984-B Macrocyclic derivatives, preparation method and application thereof 浙江海正药业股份有限公司 2024-03-15 CN disclosed
CN-113727984-A Macrocyclic derivative, preparation method and application thereof 浙江海正药业股份有限公司 2021-11-30 CN disclosed
WO-2020233645-A1 MACROLIDE DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF 浙江海正药业股份有限公司 (CN) 2020-11-26 WO disclosed
WO-2020233645-A1 MACROLIDE DERIVATIVES, PREPARATION METHOD AND APPLICATION THEREOF 浙江海正药业股份有限公司 (CN) 2020-11-26 WO disclosed