SCHEMBL4271221

SCHEMBL4271221

CCOc1cc(F)ccc1C(C)=O

nearest known ligand 0.61

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 1/20 0.61
TSHR P16473 1/20 0.61
KDM4E B2RXH2 2/20 0.53
LMNA P02545 3/20 0.51
MAPT P10636 2/20 0.51
L3MBTL1 Q9Y468 2/20 0.51
MAOB P27338 5/20 0.50
MAOA P21397 2/20 0.50
CA9 Q16790 1/20 0.49
TDP1 Q9NUW8 2/20 0.47
CREBBP Q92793 1/20 0.45
MRGPRX1 Q96LB2 2/20 0.44
ALDH1A1 P00352 2/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CYP1A2 P05177 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C19 P33261 1/20 0.44
KMT2A Q03164 1/20 0.43
FFAR4 Q5NUL3 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30628273 1.00 CYP3A4 (0.61) CYP3A4TSHRKDM4ELMNAMAPT
SCHEMBL4203948 0.87 MAPT (0.47) CYP3A4TSHRKDM4ELMNAMAPT
SCHEMBL13637553 0.87 LMNA (0.52) CYP3A4TSHRKDM4ELMNAMAPT
SCHEMBL30628345 0.86 CYP3A4 (0.61) CYP3A4TSHRKDM4ELMNAMAPT
SCHEMBL15048810 0.86 TSHR (0.51) CYP3A4TSHRKDM4ELMNAL3MBTL1
SCHEMBL3165420 0.86 CYP3A4 (0.61) CYP3A4TSHRKDM4ELMNAMAPT
SCHEMBL12051096 0.85 ABCB1 (0.46) CYP3A4TSHRKDM4ELMNAMAPT
Hydrochloric Acid SCHEMBL30779134 0.83 MKNK1 (0.52) CYP3A4TSHRKDM4ELMNAMAPT
SCHEMBL1546433 0.83 TSHR (0.54) CYP3A4TSHRKDM4ELMNAMAPT
SCHEMBL25794823 0.83 TDP1 (0.62) CYP3A4TSHRKDM4ELMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260108497-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMACEUTICALC., LTD. (JP) 2026-04-23 US disclosed
US-20240148699-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2024-05-09 US disclosed
EP-3594211-B1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2023-10-25 EP disclosed
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORP (US) 2022-12-08 US disclosed
US-20220265613-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2022-08-25 US disclosed
US-11241423-B2 Antiproliferative compounds and methods of use thereof CELGENE CORPORATION (US) 2022-02-08 US disclosed
US-20210253582-A1 SALTS AND SOLID FORMS AND PROCESSES OF PREPARING A PI3K INHIBITOR INCYTE CORPORATION 2021-08-19 US disclosed
US-20210253582-A1 SALTS AND SOLID FORMS AND PROCESSES OF PREPARING A PI3K INHIBITOR INCYTE CORPORATION 2021-08-19 US disclosed
WO-2021158891-A1 SALTS AND SOLID FORMS AND PROCESSES OF PREPARING A PI3K INHIBITOR INCYTE CORPORATION (US) 2021-08-12 WO disclosed
WO-2021158891-A1 SALTS AND SOLID FORMS AND PROCESSES OF PREPARING A PI3K INHIBITOR INCYTE CORPORATION (US) 2021-08-12 WO disclosed
US-9499514-B2 Antiproliferative compounds and methods of use thereof CELGENE CORPORATION (US) 2016-11-22 US disclosed
WO-2016007848-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORPORATION (US) 2016-01-14 WO disclosed
US-20160009683-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF CELGENE CORPORATION 2016-01-14 US disclosed
EP-1954684-B1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMA CO LTD (JP) 2014-05-07 EP disclosed
US-20140100226-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2014-04-10 US disclosed
US-8637559-B2 Oxazole compound and pharmaceutical composition OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2014-01-28 US disclosed
US-20090221586-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2009-09-03 US disclosed
EP-1954684-A2 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION Otsuka Pharmaceutical Co., Ltd. (JP) 2008-08-13 EP disclosed
WO-2007058338-A9 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMA CO LTD (JP) 2007-11-01 WO disclosed
WO-2007058338-A2 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION OTSUKA PHARMACEUTICAL CO., LTD. (JP) 2007-05-24 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (9 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220387413-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX CYP3A4 3767/4885TSHR 4516/4885KDM4E 1196/4885
US-20140100226-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION PDE3B, PDE4A, PDE3A CYP3A4 32/4885TSHR 2109/4885KDM4E 1260/4885
US-20240148699-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION PDE3B, PDE4A, PDE3A CYP3A4 32/4885TSHR 2109/4885KDM4E 1260/4885
US-20260108497-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION PDE7B, PDE4B, PDE1B CYP3A4 77/4885TSHR 1378/4885KDM4E 907/4885
US-20090221586-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION PDE3B, PDE4A, PDE3A CYP3A4 32/4885TSHR 2109/4885KDM4E 1260/4885
US-11241423-B2 Antiproliferative compounds and methods of use thereof MCL1, MKI67, BAX CYP3A4 3767/4885TSHR 4516/4885KDM4E 1196/4885
US-20160009683-A1 ANTIPROLIFERATIVE COMPOUNDS AND METHODS OF USE THEREOF MCL1, MKI67, BAX CYP3A4 3767/4885TSHR 4516/4885KDM4E 1196/4885
US-20210253582-A1 SALTS AND SOLID FORMS AND PROCESSES OF PREPARING A PI3K INHIBITOR PIK3CD, PIK3CA, PIK3CG CYP3A4 1409/4885TSHR 3428/4885KDM4E 1152/4885
US-20220265613-A1 OXAZOLE COMPOUND AND PHARMACEUTICAL COMPOSITION PDE3B, PDE4A, PDE3A CYP3A4 50/4885TSHR 1832/4885KDM4E 1383/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.