Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dibucaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.98 |
| ▸ | HPGD | P15428 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | SCN1A | P35498 | 1/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.98 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.98 |
| ▸ | GHSR | Q92847 | 1/20 | 0.98 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.98 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.98 |
| ▸ | RAD52 | P43351 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibucaine SCHEMBL31303 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL19555661 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL29555902 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL34473 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL29810833 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL11487195 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL27866755 | 0.97 | KDM4E (0.96) | KDM4EALDH1A1ALOX15HTTGAA | |
| SCHEMBL28339270 | 0.96 | KDM4E (0.94) | KDM4EALDH1A1ALOX15HTTGAA | |
| SCHEMBL28339269 | 0.95 | KDM4E (0.92) | KDM4EALDH1A1ALOX15HTTGAA | |
| SCHEMBL28339274 | 0.94 | ALDH1A1 (0.90) | KDM4EALDH1A1ALOX15HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220202793-A1 | SUSTAINED RELEASE LOCAL ANESTHETIC HYDROGEL COMPOSITION | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2022-06-30 | — | — | US | disclosed |
| WO-2021232157-A1 | SUSTAINED RELEASE PHARMACEUTICAL COMPOSITION | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2021-11-25 | — | — | WO | disclosed |
| WO-2020232539-A1 | SUSTAINED RELEASE LOCAL ANESTHETIC HYDROGEL COMPOSITION | THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) | 2020-11-26 | — | — | WO | disclosed |
| CN-101199454-A | Fragrance release | PROCTER & GAMBLE (US) | 2008-06-18 | — | — | CN | disclosed |
| CN-1649565-A | Fragrance delivery agent | PROCTER & GAMBLE (US) | 2005-08-03 | — | — | CN | disclosed |