Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dibucaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | CYP1A2 | P05177 | 1/20 | 1.00 |
| ▸ | CYP2D6 | P10635 | 1/20 | 1.00 |
| ▸ | SCN1A | P35498 | 1/20 | 1.00 |
| ▸ | OPRK1 | P41145 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | CACNA1C | Q13936 | 1/20 | 1.00 |
| ▸ | GHSR | Q92847 | 1/20 | 1.00 |
| ▸ | SCN2A | Q99250 | 1/20 | 1.00 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 0.98 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.98 |
| ▸ | TP53 | P04637 | 3/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibucaine SCHEMBL29810833 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Dibucaine SCHEMBL22688962 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Dibucaine SCHEMBL31303 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Dibucaine SCHEMBL29555902 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Dibucaine SCHEMBL19555661 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Dibucaine SCHEMBL27866755 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| Dibucaine SCHEMBL11487195 | 0.97 | KDM4E (0.96) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL28339270 | 0.97 | KDM4E (0.94) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL28339269 | 0.96 | KDM4E (0.92) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL28339274 | 0.95 | ALDH1A1 (0.90) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 19273 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144801-A1 | COMPOSITIONS AND METHODS FOR PREVENTING OR TREATING MUSCLE CONDITIONS | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2026-05-28 | — | — | US | claimed |
| US-20260137637-A1 | ANESTHETIC AGENT MICRO AND NANO PARTICLES, AND METHODS OF MAKING AND USING THE SAME | HAAS ERIC (US) | 2026-05-21 | — | — | US | claimed |
| EP-4743122-A1 | THERAPEUTIC SEALANTS BASED UPON DRUG CONJUGATES | The Johns Hopkins University (US) | 2026-05-20 | — | — | EP | claimed |
| US-12622873-B2 | Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2026-05-12 | — | — | US | claimed |
| EP-4735042-A1 | MERCERIZED DECELLULARIZED PARTICLES FOR SLOW RELEASE APPLICATIONS AND METHODS THEREOF | Spiderwort Biotechnologies Inc. (CA) | 2026-05-06 | — | — | EP | claimed |
| US-20260115156-A1 | INJECTABLE COMPOSITION INCLUDING HYDROGEL CONTAINING ANESTHETIC AGENT | UNIV KOREA RES & BUS FOUND (KR) | 2026-04-30 | — | — | US | claimed |
| EP-3723819-B1 | WOUND DRESSING | ANIMAL ETHICS PTY LTD (AU) | 2026-04-22 | — | — | EP | claimed |
| US-20260083666-A1 | METHOD OF TREATING DISEASE | CREWS THOMAS M (US) | 2026-03-26 | — | — | US | claimed |
| EP-4694866-A1 | SUSTAINED RELEASE STABLE EMULSION PHARMACEUTICAL FORMULATIONS | Insitu Biologics, Inc. (US) | 2026-02-18 | — | — | EP | claimed |
| EP-4082547-B1 | SYSTEMS, METHODS, AND COMPOSITIONS FOR CROSS-LINKING TREATMENTS OF AN EYE | AVEDRO INC (US) | 2026-02-04 | — | — | EP | claimed |
| EP-0036138-A2 | Composition of matter for topical application comprising a bio-affecting agent and N,N-diethyl-m-toluamide | MERCK & CO. INC. (US) | 1981-09-23 | — | — | EP | claimed |
| US-4248855-A | SALT FORMING NITROGEN COMPOUND AND A POLYMER CONTAINING AN ACID GROUP FOR FORMING A SUSTAINED RELEASE COMPOSITION | HYDROPHILICS INTERNATIONAL, INC. (US) | 1981-02-03 | — | — | US | claimed |
| US-4235236-A | Device for dispensing drug by combined diffusional and osmotic operations | ALZA CORPORATION (US) | 1980-11-25 | — | — | US | claimed |
| US-4186185-A | Compositions comprising arylene substituted poly(orthoesters) containing useful agents | ALZA CORPORATION (US) | 1980-01-29 | — | — | US | claimed |
| US-4181725-A | BROMOPHENACYL BROMIDE, TOCOPHEROL, MEPACRINE, (HYDROXY)CHLOROQUINE, DIBUCAINE, TETRACAINE, LIDOCAINE, BUTACAINE, PROCAINE, EDTA | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 1980-01-01 | — | — | US | claimed |
| EP-0002426-A1 | Antiperspirant | Playtex-Wallco Aktiebolag (SE) | 1979-06-13 | — | — | EP | claimed |
| US-4148917-A | PENETRATION | THE PROCTER & GAMBLE COMPANY (US) | 1979-04-10 | — | — | US | claimed |
| US-4118480-A | PHENOL, MENTHOL, BISMUTH SUBNITRATE, DIBUCAINE, AND PULVERIZED STARCH | Stoelker, Charles V. (US) | 1978-10-03 | — | — | US | claimed |
| US-4105760-A | Local anaesthetic salts of chondroitinsulfate compounds | SZEJTLI JOZSEF | 1978-08-08 | — | — | US | claimed |
| US-4066747-A | Polymeric orthoesters housing beneficial drug for controlled release therefrom | ALZA CORPORATION (US) | 1978-01-03 | — | — | US | claimed |