Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dibucaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN5A known ✓ | Q14524 | 1/20 | 0.98 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | ALOX15 | P16050 | 1/20 | 1.00 |
| ▸ | HTT | P42858 | 1/20 | 1.00 |
| ▸ | GAA | P10253 | 2/20 | 0.98 |
| ▸ | HPGD | P15428 | 2/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.98 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.98 |
| ▸ | SCN1A | P35498 | 1/20 | 0.98 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.98 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.98 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.98 |
| ▸ | GHSR | Q92847 | 1/20 | 0.98 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.98 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.98 |
| ▸ | RAD52 | P43351 | 2/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dibucaine SCHEMBL22688962 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL19555661 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL29555902 | 1.00 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL29810833 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL34473 | 0.99 | KDM4E (1.00) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL11487195 | 0.98 | KDM4E (0.96) | KDM4EALDH1A1ALOX15HTTGAA | |
| Dibucaine SCHEMBL27866755 | 0.97 | KDM4E (0.96) | KDM4EALDH1A1ALOX15HTTGAA | |
| SCHEMBL28339270 | 0.96 | KDM4E (0.94) | KDM4EALDH1A1ALOX15HTTGAA | |
| SCHEMBL28339269 | 0.95 | KDM4E (0.92) | KDM4EALDH1A1ALOX15HTTGAA | |
| SCHEMBL28339274 | 0.94 | ALDH1A1 (0.90) | KDM4EALDH1A1ALOX15HTTGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 8185 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137637-A1 | ANESTHETIC AGENT MICRO AND NANO PARTICLES, AND METHODS OF MAKING AND USING THE SAME | HAAS ERIC (US) | 2026-05-21 | — | — | US | claimed |
| US-12622873-B2 | Composition of matter comprising liposomes embedded in a polymeric matrix and methods of using same | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2026-05-12 | — | — | US | claimed |
| EP-4735042-A1 | MERCERIZED DECELLULARIZED PARTICLES FOR SLOW RELEASE APPLICATIONS AND METHODS THEREOF | Spiderwort Biotechnologies Inc. (CA) | 2026-05-06 | — | — | EP | claimed |
| US-20260083666-A1 | METHOD OF TREATING DISEASE | CREWS THOMAS M (US) | 2026-03-26 | — | — | US | claimed |
| EP-4436552-B1 | GASTRO-RETENTIVE ORAL DOSAGE UNIT CONTAINING A LOCAL ANAESTHETIC | OREXA B V (NL) | 2026-02-04 | — | — | EP | claimed |
| US-12527756-B2 | Anesthetic agent micro and nano particles, and methods of making and using the same | HAAS ERIC (US) | 2026-01-20 | — | — | US | claimed |
| US-20250332120-A1 | COMPOSITION FOR EXTERNAL PREPARATION | KAO CORPORATION (JP) | 2025-10-30 | — | — | US | claimed |
| US-20250319025-A9 | COMPOSITIONS COMPRISING MODIFIED PHOSPHOLIPIDS AND USES THEREOF | THE CHILDREN'S MEDICAL CENTER CORPORATION (US) | 2025-10-16 | — | — | US | claimed |
| US-20250259704-A1 | SYSTEMS AND METHODS FOR CELL-FREE ITERATIVE SITE SATURATION MUTAGENESIS AND ITS APPLICATION FOR THE DIRECTED EVOLUTION OF ENZYMES CATALYZING UNNATURAL REACTIONS | U.S. DEPARTMENT OF ENERGY | 2025-08-14 | — | — | US | claimed |
| EP-4583875-A1 | CHEMICAL DISBUDDING METHOD | Welfare Concepts Limited (NZ) | 2025-07-16 | — | — | EP | claimed |
| WO-1989000047-A1 | HEMORRHOIDAL, OTHER COMPOSITIONS AND METHODS OF TREATMENT | PACKMAN ELIAS W (US) | 1989-01-12 | — | — | WO | claimed |
| EP-0275550-A1 | Adhesive device for application to body tissue | TEIKOKU SEIYAKU KABUSHIKI KAISHA (JP) | 1988-07-27 | — | — | EP | claimed |
| EP-0250572-A1 | GASTRO-OESOPHAGEAL REFLUX COMPOSITION | THE UNIVERSITY OF MELBOURNE (AU) | 1988-01-07 | — | — | EP | claimed |
| WO-1987004077-A1 | GASTRO-OESOPHAGEAL REFLUX COMPOSITION | THE UNIVERSITY OF MELBOURNE (AU) | 1987-07-16 | — | — | WO | claimed |
| US-4659714-A | PROLONGATION WITH VASOCONSTRICTORS; REVERSAL WITH ADRENERGIC BLOCKING AGENTS | DENTSPLY, LTD. (GB) | 1987-04-21 | — | — | US | claimed |
| EP-0189861-A2 | Percutaneous absorption accelerator for ionic water-soluble medicine | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1986-08-06 | — | — | EP | claimed |
| EP-0160191-A1 | Kit for treating mammals | Dentsply Limited (GB) | 1985-11-06 | — | — | EP | claimed |
| EP-0126684-A2 | Drug delivery system utilizing thermosetting gels | MERCK & CO. INC. (US) | 1984-11-28 | — | — | EP | claimed |
| US-4474751-A | SUSTAINED RELEASE USING AN ALKYLENEDIAMINE-MODIFIED ETHYLENE OXIDE-PROPYLENE OXIDE COPOLYMER | MERCK & CO., INC. (US) | 1984-10-02 | — | — | US | claimed |
| US-4005191-A | CALCIUM CARBONATE, MAGNESIUM AND ALUMINUM HYDROXIDE, LANOLIN | CLARK MARY G | 1977-01-25 | — | — | US | claimed |