Sugi Predict

Sugi Predict / Compounds / SCHEMBL22691663

SCHEMBL22691663

SCHEMBL22691663

O=C1NCSc2ncccc21

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ ALDH1A1 P00352 1/20 0.44
▸ ALOX15 P16050 1/20 0.44
▸ MAPK10 P53779 1/20 0.44
▸ HSD17B10 Q99714 1/20 0.44
▸ TDP2 O95551 1/20 0.39
▸ NSD2 O96028 1/20 0.39
▸ ABL1 P00519 1/20 0.39
▸ PLCG1 P19174 1/20 0.39
▸ CES1 P23141 1/20 0.39
▸ PAX8 Q06710 1/20 0.39
▸ RIN1 Q13671 1/20 0.39
▸ MEN1 O00255 1/20 0.39
▸ THRB P10828 1/20 0.39
▸ BLM P54132 1/20 0.39
▸ KMT2A Q03164 1/20 0.39
▸ TDP1 Q9NUW8 1/20 0.39
▸ GAA P10253 1/20 0.39
▸ CYP1A2 P05177 1/20 0.39
▸ SMN1; SMN2 Q16637 1/20 0.39
▸ CA12 O43570 3/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26687028 0.82 ALDH1A1 (0.42) ALDH1A1ALOX15MAPK10HSD17B10TDP2
SCHEMBL9542444 0.73 GAA (0.42) ALDH1A1ALOX15MAPK10HSD17B10TDP2
SCHEMBL31557108 0.73 CDC25B (0.33) CDC25B
SCHEMBL14990432 0.72 — —
SCHEMBL8658609 0.71 CA12 (0.45) ALDH1A1ALOX15MAPK10HSD17B10MEN1
SCHEMBL566902 0.70 TDP2 (0.39) ALDH1A1ALOX15MAPK10HSD17B10TDP2
SCHEMBL2223651 0.67 CA12 (0.50) TDP2NSD2ABL1PLCG1CES1
SCHEMBL4313114 0.67 TDP1 (0.39) ALDH1A1ALOX15MAPK10HSD17B10TDP2
SCHEMBL12849394 0.66 ALDH1A1 (0.35) ALDH1A1ALOX15MAPK10HSD17B10TDP2
SCHEMBL699878 0.65 CYP1A2 (0.58) ALDH1A1TDP2NSD2ABL1PLCG1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250326727-A1 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING PENN STATE RES FOUND (US) 2025-10-23 — — US disclosed
US-12304895-B2 2,3-diaryl-2,3-dihydro-4H-1,3-thiazin-4-one compounds and methods for making THE PENN STATE RESEARCH FOUNDATION UNIVERSITY (US) 2025-05-20 — — US disclosed
US-20220213046-A1 2,3-Diaryl-2,3-Dihydro-4H-1,3-Thiazin-4-One Compounds and Methods for Making THE PENN STATE RESEARCH FOUNDATION (US) 2022-07-07 — — US disclosed
WO-2020237063-A1 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING THE PENN STATE RESEARCH FOUNDATION (US) 2020-11-26 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220213046-A1 2,3-Diaryl-2,3-Dihydro-4H-1,3-Thiazin-4-One Compounds and Methods for Making CCNL2, TTL, ATXN2L ALDH1A1 1038/4885ALOX15 3426/4885MAPK10 2891/4885
US-12304895-B2 2,3-diaryl-2,3-dihydro-4H-1,3-thiazin-4-one compounds and methods for making CCNL2, TTL, ATXN2L ALDH1A1 1038/4885ALOX15 3426/4885MAPK10 2891/4885
US-20250326727-A1 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING CCNL2, CDKL3, TTL ALDH1A1 1262/4885ALOX15 3610/4885MAPK10 2478/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.