Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.42 |
| ▸ | PARP11 | Q9NR21 | 2/20 | 0.42 |
| ▸ | PARP1 | P09874 | 2/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | S100A4 | P26447 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29412550 | 0.80 | HPGD (0.42) | CA12CA9L3MBTL1PARP10PARP11 | |
| SCHEMBL5850195 | 0.80 | RYR2 (0.55) | CA12CA9L3MBTL1PARP10PARP11 | |
| SCHEMBL13939432 | 0.73 | CA12 (0.63) | CA12CA9L3MBTL1PARP10PARP11 | |
| SCHEMBL13820403 | 0.73 | PARP10 (0.49) | CA9L3MBTL1PARP10PARP11PARP1 | |
| SCHEMBL3428710 | 0.72 | L3MBTL1 (0.50) | L3MBTL1HPGDTDP1POLBMAPT | |
| SCHEMBL9635081 | 0.72 | CA12 (0.52) | CA12CA9L3MBTL1PARP10PARP11 | |
| SCHEMBL14259805 | 0.71 | L3MBTL1 (0.48) | CA12CA9L3MBTL1PARP10PARP11 | |
| SCHEMBL22691663 | 0.71 | ALDH1A1 (0.44) | CA12CA9PARP10PARP11PARP1 | |
| SCHEMBL30970176 | 0.69 | TDP1 (0.50) | CA12CA9TDP1MAPTALDH1A1 | |
| SCHEMBL9635086 | 0.68 | BRD4 (0.45) | CA12CA9L3MBTL1PARP10PARP11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116496230-B | Preparation method of 2, 3-dihydro-4H-1, 3-benzothiazine-4-ketone | 常州大学 | 2025-02-25 | — | — | CN | claimed |
| CN-116496230-A | Preparation method of 2, 3-dihydro-4H-1, 3-benzothiazine-4-ketone | 常州大学 | 2023-07-28 | — | — | CN | claimed |
| US-20250326727-A1 | 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING | PENN STATE RES FOUND (US) | 2025-10-23 | — | — | US | disclosed |
| US-12304895-B2 | 2,3-diaryl-2,3-dihydro-4H-1,3-thiazin-4-one compounds and methods for making | THE PENN STATE RESEARCH FOUNDATION UNIVERSITY (US) | 2025-05-20 | — | — | US | disclosed |
| CN-116496230-B | Preparation method of 2, 3-dihydro-4H-1, 3-benzothiazine-4-ketone | 常州大学 | 2025-02-25 | — | — | CN | disclosed |
| CN-116496230-B | Preparation method of 2, 3-dihydro-4H-1, 3-benzothiazine-4-ketone | 常州大学 | 2025-02-25 | — | — | CN | disclosed |
| CN-117756743-A | Method for preparing dibenzothiazyl-4-ketone | 常州大学 | 2024-03-26 | — | — | CN | disclosed |
| CN-116496230-A | Preparation method of 2, 3-dihydro-4H-1, 3-benzothiazine-4-ketone | 常州大学 | 2023-07-28 | — | — | CN | disclosed |
| CN-116496230-A | Preparation method of 2, 3-dihydro-4H-1, 3-benzothiazine-4-ketone | 常州大学 | 2023-07-28 | — | — | CN | disclosed |
| US-20220213046-A1 | 2,3-Diaryl-2,3-Dihydro-4H-1,3-Thiazin-4-One Compounds and Methods for Making | THE PENN STATE RESEARCH FOUNDATION (US) | 2022-07-07 | — | — | US | disclosed |
| WO-2020237063-A1 | 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING | THE PENN STATE RESEARCH FOUNDATION (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2012154760-A1 | FUSED HETEROCYCLIC COMPOUNDS AS SODIUM CHANNEL MODULATORS | GILEAD SCIENCES, INC. (US) | 2012-11-15 | — | — | WO | disclosed |
| US-20120289493-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD SCIENCES, INC. | 2012-11-15 | — | — | US | disclosed |
| EP-0566018-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1998-08-05 | — | — | EP | disclosed |
| US-5480882-A | Benzoxazinone and benzothiazinone derivatives having cardiovascular activity | ITALFARMACO S.P.A. (IT) | 1996-01-02 | — | — | US | disclosed |
| EP-0490183-B1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO SPA (IT) | 1995-04-19 | — | — | EP | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |
| EP-0566018-A2 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1993-10-20 | — | — | EP | disclosed |
| US-5189034-A | Vasodilating, antianginal agents | ITALFARMACO S.P.A. (IT) | 1993-02-23 | — | — | US | disclosed |
| EP-0490183-A1 | Benzoxazinone and benzothiazinone derivatives endowed with cardiovascular activity | ITALFARMACO S.p.A. (IT) | 1992-06-17 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213046-A1 | 2,3-Diaryl-2,3-Dihydro-4H-1,3-Thiazin-4-One Compounds and Methods for Making | CCNL2, TTL, ATXN2L | CA12 4161/4885CA9 1962/4885L3MBTL1 1199/4885 |
| US-20120289493-A1 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | KCNJ2, CACNA1A, KCNH2 | CA12 3870/4885CA9 1845/4885L3MBTL1 4070/4885 |
| US-12304895-B2 | 2,3-diaryl-2,3-dihydro-4H-1,3-thiazin-4-one compounds and methods for making | CCNL2, TTL, ATXN2L | CA12 4161/4885CA9 1962/4885L3MBTL1 1199/4885 |
| US-20250326727-A1 | 2,3-DIARYL-2,3-DIHYDRO-4H-1,3-THIAZIN-4-ONE COMPOUNDS AND METHODS FOR MAKING | CCNL2, CDKL3, TTL | CA12 4086/4885CA9 2177/4885L3MBTL1 1139/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.