Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.48 |
| ▸ | TMEM97 | Q5BJF2 | 7/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | HRH2 | P25021 | 2/20 | 0.41 |
| ▸ | HRH1 | P35367 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR1E | P28566 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133557 | 0.90 | PARP1 (0.49) | PARP1TMEM97SIGMAR1NR1H2NR1H3 | |
| SCHEMBL22904459 | 0.90 | PARP1 (0.49) | PARP1TMEM97SIGMAR1NR1H2NR1H3 | |
| SCHEMBL20133538 | 0.90 | PARP1 (0.49) | PARP1TMEM97SIGMAR1NR1H2NR1H3 | |
| SCHEMBL24533397 | 0.85 | ABCB1 (0.54) | PARP1SIGMAR1ABCB1 | |
| SCHEMBL12780700 | 0.83 | SIGMAR1 (0.52) | PARP1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL8240100 | 0.83 | SIGMAR1 (0.52) | PARP1SIGMAR1NR1H2NR1H3 | |
| SCHEMBL2420439 | 0.82 | PARP1 (0.63) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL20129602 | 0.82 | PARP1 (0.63) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL6334954 | 0.82 | PARP1 (0.63) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL30794088 | 0.81 | PARP1 (0.51) | PARP1PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10844013-B2 | Phenyl amino piperidine mTORC inhibitors and uses thereof | NAVITOR PHARMACEUTICALS, INC. (US) | 2020-11-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10844013-B2 | Phenyl amino piperidine mTORC inhibitors and uses thereof | MTOR, RICTOR, RPTOR | PARP1 718/4885TMEM97 519/4885SIGMAR1 1261/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.