Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.48 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.44 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.44 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.44 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22693284 | 0.85 | PARP1 (0.48) | ABCB1SIGMAR1PARP1 | |
| SCHEMBL6220780 | 0.83 | SIGMAR1 (0.61) | ABCB1SIGMAR1KEAP1NFE2L2MAPT | |
| SCHEMBL30750666 | 0.83 | SIGMAR1 (0.61) | ABCB1SIGMAR1KEAP1NFE2L2MAPT | |
| SCHEMBL20133557 | 0.82 | PARP1 (0.49) | ABCB1SIGMAR1PARP1HTTKLK7 | |
| SCHEMBL22904459 | 0.82 | PARP1 (0.49) | ABCB1SIGMAR1PARP1HTTKLK7 | |
| SCHEMBL20133538 | 0.82 | PARP1 (0.49) | ABCB1SIGMAR1PARP1HTTKLK7 | |
| SCHEMBL31315361 | 0.81 | LMNA (0.48) | ABCB1SIGMAR1KEAP1NFE2L2MAPT | |
| SCHEMBL25815044 | 0.80 | LMNA (0.47) | ABCB1SIGMAR1KEAP1NFE2L2MAPT | |
| SCHEMBL8240100 | 0.80 | SIGMAR1 (0.52) | SIGMAR1PARP1 | |
| SCHEMBL12780700 | 0.80 | SIGMAR1 (0.52) | SIGMAR1PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022133281-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS | CIDARA THERAPEUTICS, INC. (US) | 2022-06-23 | — | — | WO | disclosed |
| WO-2022133281-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF HUMAN IMMUNODEFICIENCY VIRUS | CIDARA THERAPEUTICS, INC. (US) | 2022-06-23 | — | — | WO | disclosed |