Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.44 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.42 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 4/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.41 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20133538 | 1.00 | PARP1 (0.49) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL20133557 | 1.00 | PARP1 (0.49) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL22693284 | 0.90 | PARP1 (0.48) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL21844096 | 0.86 | PARP1 (0.46) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL22904330 | 0.85 | PARP1 (0.45) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL22904439 | 0.85 | PARP1 (0.45) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL12780700 | 0.85 | SIGMAR1 (0.52) | PARP1NR1H2NR1H3SIGMAR1DPP4 | |
| SCHEMBL8240100 | 0.85 | SIGMAR1 (0.52) | PARP1NR1H2NR1H3SIGMAR1DPP4 | |
| SCHEMBL20129602 | 0.84 | PARP1 (0.63) | PARP1NR1H2NR1H3PDK1PDK2 | |
| SCHEMBL2420439 | 0.84 | PARP1 (0.63) | PARP1NR1H2NR1H3PDK1PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230357233-A1 | HETEROARYL COMPOUNDS, PREPARATION METHODS AND USES THEREOF | InventisBio Co., Ltd. (CN) | 2023-11-09 | — | — | US | disclosed |
| US-20230219986-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | QILU PHARMACEUTICAL CO., LTD. (CN) | 2023-07-13 | — | — | US | disclosed |
| US-11649235-B2 | Pan-tropic entry inhibitors | EMORY UNIVERSITY (US) | 2023-05-16 | — | — | US | disclosed |
| US-20210017178-A1 | Pan-Tropic Entry nhibitors | UNIV EMORY (US) | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11649235-B2 | Pan-tropic entry inhibitors | CXCR4, CCR5, CXCL12 | PARP1 630/4885NR1H2 297/4885NR1H3 238/4885 |
| US-20210017178-A1 | Pan-Tropic Entry nhibitors | CXCR4, CXCL12, CCR5 | PARP1 473/4885NR1H2 606/4885NR1H3 598/4885 |
| US-20230219986-A1 | NOVEL AMINOPYRIMIDINE EGFR INHIBITOR | EGFR, ERBB2, ERBB4 | PARP1 1748/4885NR1H2 2763/4885NR1H3 3019/4885 |
| US-20230357233-A1 | HETEROARYL COMPOUNDS, PREPARATION METHODS AND USES THEREOF | KRAS, NRAS, HRAS | PARP1 562/4885NR1H2 738/4885NR1H3 819/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.