SCHEMBL2269389

SCHEMBL2269389

CCN(CC)CCCCN1c2ccccc2Oc2ccc(Cl)cc21

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 1.00
KMT2A Q03164 4/20 1.00
PIM1 P11309 3/20 1.00
TDP1 Q9NUW8 3/20 1.00
SIGMAR1 Q99720 3/20 0.45
HDAC3 O15379 1/20 0.45
TUBB4A P04350 1/20 0.45
TUBB P07437 1/20 0.45
TUBA3C P0DPH7 1/20 0.45
HDAC4 P56524 1/20 0.45
TUBA1B P68363 1/20 0.45
TUBA4A P68366 1/20 0.45
TUBB4B P68371 1/20 0.45
TUBB3 Q13509 1/20 0.45
HDAC1 Q13547 1/20 0.45
TUBB2A Q13885 1/20 0.45
TUBB8 Q3ZCM7 1/20 0.45
TUBA3E Q6PEY2 1/20 0.45
TUBA1A Q71U36 1/20 0.45
HDAC7 Q8WUI4 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29767032 1.00 MEN1 (1.00) MEN1KMT2APIM1TDP1SIGMAR1
Hydrochloric Acid SCHEMBL29358850 0.99 MEN1 (0.98) MEN1KMT2APIM1TDP1SIGMAR1
Hydrochloric Acid SCHEMBL1559590 0.99 MEN1 (0.98) MEN1KMT2APIM1TDP1SIGMAR1
SCHEMBL15496911 0.99 MEN1 (0.98) MEN1KMT2APIM1TDP1SIGMAR1
SCHEMBL6106184 0.96 MEN1 (0.93) MEN1KMT2APIM1TDP1SIGMAR1
SCHEMBL9419622 0.88 PIM1 (0.78) MEN1KMT2APIM1TDP1SIGMAR1
SCHEMBL9419633 0.84 PIM1 (0.71) MEN1KMT2APIM1TDP1SIGMAR1
SCHEMBL29444947 0.83 MEN1 (0.71) MEN1KMT2APIM1TDP1SIGMAR1
SCHEMBL13305235 0.79 MEN1 (0.65) MEN1KMT2APIM1TDP1SIGMAR1
SCHEMBL6106996 0.76 MEN1 (0.61) MEN1KMT2APIM1TDP1SIGMAR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20210102165-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2021-04-08 US claimed
US-20180320133-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-11-08 US claimed
EP-3370743-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY City of Hope (US) 2018-09-12 EP claimed
WO-2017079528-A9 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY CITY OF HOPE (US) 2017-06-15 WO claimed
WO-2017079528-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY CITY OF HOPE (US) 2017-05-11 WO claimed
US-20240207292-A1 BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS TRUSTEES OF TUFTS COLLEGE 2024-06-27 US disclosed
EP-4313033-A1 BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS TRUSTEES OF TUFTS COLLEGE (US) 2024-02-07 EP disclosed
WO-2023218243-A1 LAG-3/PD-L1 BINDING FUSION PROTEINS AVACTA LIFE SCIENCES LIMITED (GB) 2023-11-16 WO disclosed
EP-4262878-A1 FAP-ACTIVATED RADIOTHERANOSTICS, AND USES RELATED THERETO TRUSTEES OF TUFTS COLLEGE (US) 2023-10-25 EP disclosed
US-20230330275-A1 FAP-TARGETED RADIOPHARMACEUTICALS AND IMAGING AGENTS, AND USES RELATED THERETO TRUSTEES OF TUFTS COLLEGE 2023-10-19 US disclosed
US-11707539-B2 FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto TRUSTEES OF TUFTS COLLEGE (US) 2023-07-25 US disclosed
US-20230149295-A1 INFLAMMATORY BOWEL DISEASE STEM CELLS, AGENTS WHICH TARGET IBD STEM CELLS, AND USES RELATED THERETO UNIVERSITY OF HOUSTON SYSTEM (US) 2023-05-18 US disclosed
EP-2524232-A2 METHODS FOR PREDICTING RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER TO THERAPY Nestec S.A. (CH) 2012-11-21 EP disclosed
US-20110178076-A1 MEDICAL INTERVENTION IN HAEMATOLOGICAL CANCERS MEDIZINISCHE UNIVERSITAT INNSBRUCK 2011-07-21 US disclosed
US-20110178076-A1 MEDICAL INTERVENTION IN HAEMATOLOGICAL CANCERS MEDIZINISCHE UNIVERSITAT INNSBRUCK 2011-07-21 US disclosed
WO-2011088149-A2 METHODS FOR PREDICTING RESPONSE OF TRIPLE-NEGATIVE BREAST CANCER TO THERAPY PROMETHEUS LABORATORIES INC. (US) 2011-07-21 WO disclosed
EP-2179037-A2 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT Nodality, Inc. (US) 2010-04-28 EP disclosed
WO-2009144009-A1 MEDICAL INTERVENTION IN HAEMATOLOGICAL CANCERS MEDIZINISCHE UNIVERSITÄT INNSBRUCK (AT) 2009-12-03 WO disclosed
US-20090142319-A1 METHOD TO EXPAND nTREG CELLS USING PI-3K ANTAGONIST THERAKOS, INC. 2009-06-04 US disclosed
WO-2009025847-A2 METHODS FOR DIAGNOSIS, PROGNOSIS AND METHODS OF TREATMENT NODALITY, INC. (US) 2009-02-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180320133-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY CD4, ICOS, CD2 MEN1 3640/4885KMT2A 1396/4885PIM1 1998/4885
US-20230330275-A1 FAP-TARGETED RADIOPHARMACEUTICALS AND IMAGING AGENTS, AND USES RELATED THERETO FAP, APC, FIBP MEN1 1985/4885KMT2A 4040/4885PIM1 1424/4885
US-11707539-B2 FAP-targeted radiopharmaceuticals and imaging agents, and uses related thereto FAP, APC, FIBP MEN1 1985/4885KMT2A 4040/4885PIM1 1424/4885
US-20110178076-A1 MEDICAL INTERVENTION IN HAEMATOLOGICAL CANCERS PIK3CA, PI4KB, PTEN MEN1 207/4885KMT2A 77/4885PIM1 631/4885
US-20230149295-A1 INFLAMMATORY BOWEL DISEASE STEM CELLS, AGENTS WHICH TARGET IBD STEM CELLS, AND USES RELATED THERETO EPCAM, FABP2, TPMT MEN1 4832/4885KMT2A 577/4885PIM1 2636/4885
US-20240207292-A1 BORONIC ACID COMPOUNDS, COMPOSITIONS AND METHODS BCL6B, BCL6, BTD MEN1 180/4885KMT2A 1084/4885PIM1 2317/4885
US-20210102165-A1 METHODS FOR PREPARING CELLS FOR ADOPTIVE T CELL THERAPY CD4, ICOS, CD2 MEN1 3640/4885KMT2A 1396/4885PIM1 1998/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.