Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTUD7B | Q6GQQ9 | 14/20 | 0.44 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | MMP12 | P39900 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24307027 | 0.94 | OTUD7B (0.42) | OTUD7BMAP4K1AKR1B1HSD11B1 | |
| SCHEMBL30890516 | 0.84 | OTUD7B (0.39) | OTUD7BMAP4K1 | |
| SCHEMBL21352872 | 0.81 | OTUD7B (0.44) | OTUD7BMAP4K1AKR1B1 | |
| SCHEMBL22803136 | 0.81 | OTUD7B (0.41) | OTUD7BMAP4K1AKR1B1HSD11B1 | |
| SCHEMBL24306793 | 0.78 | OTUD7B (0.44) | OTUD7BMAP4K1 | |
| SCHEMBL24306821 | 0.76 | OTUD7B (0.39) | OTUD7B | |
| SCHEMBL27244637 | 0.76 | OTUD7B (0.33) | OTUD7B | |
| SCHEMBL27244749 | 0.75 | OTUD7B (0.38) | OTUD7B | |
| SCHEMBL27244854 | 0.73 | OTUD7B (0.37) | OTUD7B | |
| SCHEMBL24306372 | 0.73 | OTUD7B (0.42) | OTUD7BHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020237025-A1 | SUBSTITUTED EXO-METHYLENE-OXINDOLES WHICH ARE HPK1/MAP4K1 INHIBITORS | GILEAD SCIENCES, INC. (US) | 2020-11-26 | — | — | WO | disclosed |