Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTUD7B | Q6GQQ9 | 14/20 | 0.42 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22695464 | 0.94 | OTUD7B (0.44) | OTUD7BMAP4K1HSD11B1AKR1B1 | |
| SCHEMBL30890516 | 0.81 | OTUD7B (0.39) | OTUD7BMAP4K1 | |
| SCHEMBL24306372 | 0.79 | OTUD7B (0.42) | OTUD7BHSD11B1 | |
| SCHEMBL24306371 | 0.78 | OTUD7B (0.38) | OTUD7B | |
| SCHEMBL15911927 | 0.77 | BRD4 (0.33) | HSD11B1 | |
| SCHEMBL21352872 | 0.76 | OTUD7B (0.44) | OTUD7BMAP4K1AKR1B1 | |
| SCHEMBL22803136 | 0.75 | OTUD7B (0.41) | OTUD7BMAP4K1HSD11B1AKR1B1 | |
| SCHEMBL24306294 | 0.74 | OTUD7B (0.34) | OTUD7B | |
| SCHEMBL27244637 | 0.74 | OTUD7B (0.33) | OTUD7B | |
| SCHEMBL24306751 | 0.73 | MMP12 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365558-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2023-11-16 | — | — | US | disclosed |
| US-20230365558-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | MEDSHINE DISCOVERY INC. (CN) | 2023-11-16 | — | — | US | disclosed |
| EP-4219461-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | Medshine Discovery Inc. (CN) | 2023-08-02 | — | — | EP | disclosed |
| WO-2022063094-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | 南京明德新药研发有限公司 | 2022-03-31 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230365558-A1 | TETRAHYDROISOQUINOLINE DERIVATIVE AND USE THEREOF | CYP3A7, UGT2B7, SFPQ | OTUD7B 68/4885MAP4K1 1095/4885HSD11B1 440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.