Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OTUD7B | Q6GQQ9 | 14/20 | 0.41 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22695464 | 0.81 | OTUD7B (0.44) | OTUD7BMAP4K1HSD11B1AKR1B1 | |
| SCHEMBL21352872 | 0.78 | OTUD7B (0.44) | OTUD7BMAP4K1AKR1B1 | |
| SCHEMBL24307027 | 0.75 | OTUD7B (0.42) | OTUD7BMAP4K1HSD11B1AKR1B1 | |
| SCHEMBL24306793 | 0.74 | OTUD7B (0.44) | OTUD7BMAP4K1CRBN | |
| SCHEMBL22803135 | 0.74 | ALDH1A1 (0.35) | — | |
| SCHEMBL18352011 | 0.74 | NR3C2 (0.42) | — | |
| SCHEMBL24306821 | 0.73 | OTUD7B (0.39) | OTUD7BCRBN | |
| SCHEMBL13657938 | 0.72 | BRD4 (0.33) | CRBNHSD11B1 | |
| SCHEMBL22803132 | 0.70 | MAP4K1 (0.42) | OTUD7BMAP4K1CRBN | |
| SCHEMBL26766785 | 0.70 | OTUD7B (0.34) | OTUD7BMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12037342-B2 | Substituted eneoxindoles and uses thereof | GILEAD SCIENCES, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-12037342-B2 | Substituted eneoxindoles and uses thereof | GILEAD SCIENCES, INC. (US) | 2024-07-16 | — | — | US | disclosed |
| US-20230183262-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
| US-20230183262-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2023-06-15 | — | — | US | disclosed |
| US-20200392153-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | GILEAD SCIENCES, INC. | 2020-12-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230183262-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | HIPK1, HPGDS, HIPK3 | OTUD7B 1342/4885MAP4K1 122/4885CRBN 3912/4885 |
| US-12037342-B2 | Substituted eneoxindoles and uses thereof | HIPK1, HPGDS, HIPK3 | OTUD7B 1342/4885MAP4K1 122/4885CRBN 3912/4885 |
| US-20200392153-A1 | SUBSTITUTED ENEOXINDOLES AND USES THEREOF | HIPK1, HPGDS, HIPK3 | OTUD7B 1342/4885MAP4K1 122/4885CRBN 3912/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.