Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | BACE1 | P56817 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18947871 | 0.89 | DRD2 (0.54) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL24619896 | 0.89 | DRD2 (0.54) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL8254760 | 0.88 | DRD2 (0.64) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL6700 | 0.87 | DRD2 (0.53) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL22703621 | 0.85 | DRD2 (0.54) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL24922242 | 0.85 | DRD2 (0.51) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL25031746 | 0.84 | DRD2 (0.55) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL21815267 | 0.84 | DRD2 (0.50) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL13609474 | 0.84 | DRD2 (0.60) | DRD2TDP1SIGMAR1MEN1GAA | |
| SCHEMBL9127008 | 0.84 | DRD2 (0.60) | DRD2TDP1SIGMAR1MEN1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020236690-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | MERCK SHARP & DOHME CORP. (US) | 2020-11-26 | — | — | WO | disclosed |
| WO-2020236688-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | MERCK SHARP & DOHME CORP. (US) | 2020-11-26 | — | — | WO | disclosed |