Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 11/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22470192 | 0.92 | DRD2 (0.52) | DRD2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL22699069 | 0.85 | DRD2 (0.54) | DRD2MEN1KMT2ASIGMAR1TDP1 | |
| SCHEMBL18947871 | 0.85 | DRD2 (0.54) | DRD2MEN1KMT2ASIGMAR1TDP1 | |
| SCHEMBL24619896 | 0.85 | DRD2 (0.54) | DRD2MEN1KMT2ASIGMAR1TDP1 | |
| SCHEMBL31687516 | 0.85 | ACKR3 (0.53) | DRD2MEN1KMT2ASIGMAR1TDP1 | |
| SCHEMBL8254760 | 0.84 | DRD2 (0.64) | DRD2MEN1KMT2AALDH1A1SIGMAR1 | |
| SCHEMBL32690155 | 0.84 | DRD2 (0.47) | DRD2MEN1KMT2AALDH1A1TSHR | |
| SCHEMBL6700 | 0.84 | DRD2 (0.53) | DRD2MEN1KMT2ASIGMAR1TDP1 | |
| SCHEMBL21815267 | 0.83 | DRD2 (0.50) | DRD2MEN1KMT2ASIGMAR1TDP1 | |
| SCHEMBL9281583 | 0.82 | SMN1; SMN2 (0.50) | MEN1KMT2AALDH1A1TSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020236690-A1 | NATRIURETIC PEPTIDE RECEPTOR A AGONISTS USEFUL FOR THE TREATMENT OF CARDIOMETABOLIC DISEASES, KIDNEY DISEASE AND DIABETES | MERCK SHARP & DOHME CORP. (US) | 2020-11-26 | — | — | WO | disclosed |