Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.34 |
| ▸ | DUT | P33316 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 5/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16778074 | 0.80 | TOP2A (0.48) | TOP2AHDAC1DUTPRKCA | |
| SCHEMBL4392005 | 0.80 | TOP2A (0.48) | TOP2AHDAC1DUTPRKCA | |
| SCHEMBL19464421 | 0.80 | TOP2A (0.48) | TOP2AHDAC1DUTPRKCA | |
| SCHEMBL20019772 | 0.80 | TOP2A (0.46) | TOP2AHDAC1FKBP1APRKCA | |
| SCHEMBL20211424 | 0.78 | TOP2A (0.45) | TOP2AHDAC1FKBP1ADUTSMN1; SMN2 | |
| SCHEMBL9264253 | 0.77 | TOP2A (0.43) | TOP2A | |
| SCHEMBL6334886 | 0.77 | TOP2A (0.46) | TOP2AHDAC1DUT | |
| SCHEMBL21343867 | 0.77 | TOP2A (0.46) | TOP2AHDAC1PRKCA | |
| SCHEMBL6406006 | 0.77 | TOP2A (0.46) | TOP2AHDAC1DUT | |
| SCHEMBL8412572 | 0.75 | TOP2A (0.37) | TOP2AFKBP1ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3512860-B1 | NUCLEOSIDE AND NUCLEOTIDE ANALOGUES BEARING A QUATERNARY ALL-CARBON STEREOGENIC CENTER AT THE 2' POSITION AND METHODS OF USE AS A CARDIOPROTECTIVE AGENT | LCB PHARMA INC (CA) | 2020-11-25 | — | — | EP | disclosed |