Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | PRKCA | P17252 | 6/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16778074 | 1.00 | TOP2A (0.48) | TOP2AHDAC1PRKCADUT | |
| SCHEMBL19464421 | 1.00 | TOP2A (0.48) | TOP2AHDAC1PRKCADUT | |
| SCHEMBL21343867 | 0.90 | TOP2A (0.46) | TOP2AHDAC1PRKCA | |
| SCHEMBL19632819 | 0.84 | TOP2A (0.37) | TOP2APRKCA | |
| SCHEMBL20019772 | 0.84 | TOP2A (0.46) | TOP2AHDAC1PRKCA | |
| SCHEMBL22700152 | 0.80 | TOP2A (0.49) | TOP2AHDAC1PRKCADUT | |
| SCHEMBL29381478 | 0.78 | PRKCA (0.35) | TOP2APRKCA | |
| SCHEMBL20211424 | 0.77 | TOP2A (0.45) | TOP2AHDAC1DUT | |
| SCHEMBL6406006 | 0.75 | TOP2A (0.46) | TOP2AHDAC1DUT | |
| SCHEMBL6334886 | 0.75 | TOP2A (0.46) | TOP2AHDAC1DUT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180022763-A1 | Anti-Viral Compounds | ABBVIE INC. (US) | 2018-01-25 | — | — | US | disclosed |
| US-20170334941-A1 | 2',2'-DIHALO NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER | EMORY UNIVERSITY | 2017-11-23 | — | — | US | disclosed |
| US-9790252-B2 | 2-fluorinated riboses and arabinoses and methods of use and synthesis | CORNELL UNIVERSITY (US) | 2017-10-17 | — | — | US | disclosed |
| US-9676797-B2 | Anti-viral compounds | ABBVIE INC. (US) | 2017-06-13 | — | — | US | disclosed |
| US-20170057981-A1 | Anti-Viral Compounds | ABBVIE INC. (US) | 2017-03-02 | — | — | US | disclosed |
| US-20120108535-A1 | 2-FLUORINATED RIBOSES AND ARABINOSES AND METHODS OF USE AND SYNTHESIS | CORNELL UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170057981-A1 | Anti-Viral Compounds | HAVCR2, EIF2AK2, MAVS | TOP2A 950/4885HDAC1 897/4885PRKCA 1939/4885 |
| US-20170334941-A1 | 2',2'-DIHALO NUCLEOSIDE ANALOGS FOR TREATMENT OF THE FLAVIVIRIDAE FAMILY OF VIRUSES AND CANCER | HAVCR2, DERA, EIF2AK2 | TOP2A 472/4885HDAC1 2722/4885PRKCA 3728/4885 |
| US-20180022763-A1 | Anti-Viral Compounds | HAVCR2, EIF2AK2, MAVS | TOP2A 950/4885HDAC1 897/4885PRKCA 1939/4885 |
| US-20120108535-A1 | 2-FLUORINATED RIBOSES AND ARABINOSES AND METHODS OF USE AND SYNTHESIS | SLC2A2, SLC29A2, DERA | TOP2A 470/4885HDAC1 1054/4885PRKCA 4157/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.