Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP2A | P11388 | 8/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | DUT | P33316 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6334886 | 1.00 | TOP2A (0.46) | TOP2AHDAC1DUT | |
| SCHEMBL6344597 | 0.77 | POLB (0.31) | — | |
| SCHEMBL6430329 | 0.77 | POLB (0.31) | — | |
| SCHEMBL22700152 | 0.77 | TOP2A (0.49) | TOP2AHDAC1DUT | |
| SCHEMBL19464421 | 0.75 | TOP2A (0.48) | TOP2AHDAC1DUT | |
| SCHEMBL4392005 | 0.75 | TOP2A (0.48) | TOP2AHDAC1DUT | |
| SCHEMBL16778074 | 0.75 | TOP2A (0.48) | TOP2AHDAC1DUT | |
| SCHEMBL20211424 | 0.74 | TOP2A (0.45) | TOP2AHDAC1DUT | |
| SCHEMBL21343867 | 0.72 | TOP2A (0.46) | TOP2AHDAC1 | |
| SCHEMBL20019772 | 0.72 | TOP2A (0.46) | TOP2AHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919465-B2 | Method of preparing (3R, 3aS, 6aR)-3-hydroxyhexahydrofuro[2,3,-b] furan and related compounds | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2005-07-19 | — | — | US | disclosed |
| US-20040127727-A1 | Method of preparing (3R, 3aS, 6aR) -3-hydroxyhexahydrofuro [2,3,-b] furan and related compounds | BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, THE | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127727-A1 | Method of preparing (3R, 3aS, 6aR) -3-hydroxyhexahydrofuro [2,3,-b] furan and related compounds | HSD3B1, HSD3B2, CYP1B1 | TOP2A 241/4885HDAC1 3544/4885DUT 360/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.