Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.45 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.43 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.43 |
| ▸ | HIF1AN | Q9NWT6 | 1/20 | 0.43 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11442464 | 0.84 | MAPT (0.45) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL11442462 | 0.84 | MAPT (0.45) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL13631514 | 0.84 | MAPT (0.53) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL5722187 | 0.83 | CA12 (0.65) | MAPTLMNANPSR1CA12CA1 | |
| SCHEMBL22701982 | 0.82 | MAPT (0.41) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL12729834 | 0.82 | ALDH1A1 (0.42) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL69276 | 0.76 | CA12 (0.73) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL69277 | 0.76 | CA12 (0.73) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL13957564 | 0.76 | CA12 (0.73) | MAPTLMNANPSR1MEN1KMT2A | |
| SCHEMBL22701981 | 0.74 | ALDH1A1 (0.47) | MAPTLMNANPSR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411361-B1 | NRF2 ACTIVATING COMPOUNDS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2020-11-25 | — | — | EP | disclosed |