Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 2/20 | 0.36 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9515353 | 0.79 | MEN1 (0.47) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL12667811 | 0.79 | MEN1 (0.47) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL6979719 | 0.79 | MEN1 (0.47) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL13960057 | 0.77 | ALDH1A1 (0.43) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL14438096 | 0.75 | KIF11 (0.41) | ALDH1A1TSHRCES1 | |
| SCHEMBL28045551 | 0.74 | MEN1 (0.48) | ALDH1A1MEN1KMT2AMAPTTDP1 | |
| SCHEMBL1116059 | 0.71 | ALDH1A1 (0.52) | ALDH1A1TSHRMEN1KMT2AMAPT | |
| SCHEMBL11988034 | 0.70 | MEN1 (0.55) | ALDH1A1MEN1KMT2AMAPTTDP1 | |
| SCHEMBL14355669 | 0.70 | MEN1 (0.55) | ALDH1A1MEN1KMT2AMAPTTDP1 | |
| SCHEMBL22294466 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3411361-B1 | NRF2 ACTIVATING COMPOUNDS AND USES THEREOF | RIGEL PHARMACEUTICALS INC (US) | 2020-11-25 | — | — | EP | disclosed |