Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 11/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 11/20 | 0.47 |
| ▸ | MAPT | P10636 | 11/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 5/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RELA | Q04206 | 2/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.40 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12667811 | 1.00 | MEN1 (0.47) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL9515353 | 1.00 | MEN1 (0.47) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL22701979 | 0.79 | ALDH1A1 (0.48) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL13681260 | 0.78 | ALDH1A1 (0.48) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL14423827 | 0.78 | ALDH1A1 (0.48) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL22473651 | 0.77 | MAPT (0.45) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL8494529 | 0.77 | MAPT (0.57) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL8494526 | 0.77 | MAPT (0.57) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL22449456 | 0.76 | MAPT (0.44) | MEN1KMT2AMAPTTDP1SMN1; SMN2 | |
| SCHEMBL6960272 | 0.76 | MEN1 (0.44) | MEN1KMT2AMAPTTDP1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8349857-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2013-01-08 | — | — | US | disclosed |
| US-8202879-B2 | Quinazoline derivatives having tyrosine kinase inhibitory activity | SHIONOGI & CO., LTD. (JP) | 2012-06-19 | — | — | US | disclosed |
| US-20120123114-A1 | QUINAZOLINE DERIVATIVES HAVING TYROSINE KINASE INHIBITORY ACTIVITY | SHIONOGI & CO., LTD. (JP) | 2012-05-17 | — | — | US | disclosed |
| US-7967872-B2 | Azo quinolinium compounds comprising a disulphide/thiol unit, compositions containing same, process for dyeing keratin fibres and device | L'OREAL S.A. (FR) | 2011-06-28 | — | — | US | disclosed |
| US-20100263139-A1 | AZO QUINOLINIUM COMPOUNDS COMPRISING A DISULPHIDE/THIOL UNIT, COMPOSITIONS CONTAINING SAME, PROCESS FOR DYEING KERATIN FIBRES AND DEVICE | L'OREAL S.A. (FR) | 2010-10-21 | — | — | US | disclosed |
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | SHIONOGI & CO., LTD. (JP) | 2009-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143414-A1 | Quinazoline Derivatives Having Tyrosine Kinase Inhibitory Activity | ERBB2, EGFR, ABL1 | MEN1 3302/4885KMT2A 1949/4885MAPT 4100/4885 |
| US-20100263139-A1 | AZO QUINOLINIUM COMPOUNDS COMPRISING A DISULPHIDE/THIOL UNIT, COMPOSITIONS CONTAINING SAME, PROCESS FOR DYEING KERATIN FIBRES AND DEVICE | KRT18, SQOR, DSG1 | MEN1 4073/4885KMT2A 1374/4885MAPT 509/4885 |
| US-20120123114-A1 | QUINAZOLINE DERIVATIVES HAVING TYROSINE KINASE INHIBITORY ACTIVITY | ERBB2, EGFR, ABL1 | MEN1 3302/4885KMT2A 1949/4885MAPT 4100/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.