SCHEMBL2270201

SCHEMBL2270201

CC(C)(C)OC(=O)c1ccc(C2=COC(Cc3ccccc3)O2)cc1[N+](=O)[O-]

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
LMNA P02545 2/20 0.37
ABCB1 P08183 1/20 0.35
THRB P10828 2/20 0.35
CYP1A2 P05177 1/20 0.35
CYP3A4 P08684 1/20 0.35
HPGD P15428 1/20 0.35
CYP2C19 P33261 1/20 0.35
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
GAA P10253 1/20 0.33
BCHE P06276 1/20 0.33
ITGA4 P13612 1/20 0.33
ITGB7 P26010 1/20 0.33
MEN1 O00255 2/20 0.33
KMT2A Q03164 2/20 0.33
ALDH1A1 P00352 1/20 0.33
NPBWR1 P48145 1/20 0.33
MCHR1 Q99705 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270438 0.85 SLC7A5 (0.35) SMN1; SMN2LMNACYP3A4HPGDNPC1
SCHEMBL4221601 0.78 ABCB1 (0.52) LMNAABCB1MEN1KMT2AMAPT
SCHEMBL2276203 0.77 CYP1A2 (0.41) HTTSMN1; SMN2LMNACYP1A2CYP2C19
SCHEMBL2272611 0.76 MAPT (0.35) HTTSMN1; SMN2LMNACYP1A2HPGD
SCHEMBL1316419 0.73 ABCB1 (0.47) SMN1; SMN2LMNAABCB1ALDH1A1MAPT
SCHEMBL12117467 0.72 MCL1 (0.42) ABCB1ALDH1A1MAPT
SCHEMBL1316051 0.71 DRD1 (0.40) HTTSMN1; SMN2LMNAABCB1MEN1
SCHEMBL12980201 0.71 HPGD (0.38) HTTSMN1; SMN2LMNACYP1A2CYP3A4
SCHEMBL12117498 0.71 ABCB1 (0.42) SMN1; SMN2ABCB1CYP1A2MEN1KMT2A
SCHEMBL1315471 0.70 NPC1 (0.43) ABCB1NPC1RAB9AMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7999132-B2 Anthranilic acid derivative or salt thereof TOYAMA CHEMICAL CO., LTD. (JP) 2011-08-16 US disclosed
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2009-09-24 US disclosed
EP-1820795-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF TOYAMA CHEMICAL CO., LTD. (JP) 2007-08-22 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090240052-A1 NOVEL ANTHRANILIC ACID DERIVATIVE OR SALT THEREOF MMP13, MMP26, MMP11 HTT 3716/4885SMN1; SMN2 3544/4885LMNA 3235/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.