Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.44 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13460104 | 0.83 | PRMT6 (0.46) | CYP11B1CYP11B2CHRM2CHRM3PRMT6 | |
| SCHEMBL16760957 | 0.80 | SIGMAR1 (0.56) | CYP11B1CYP11B2MAOAMAOBPRMT6 | |
| SCHEMBL12372 | 0.79 | ALDH1A1 (0.49) | CYP11B1CYP11B2CHRM2CHRM3ALDH1A1 | |
| SCHEMBL17284220 | 0.78 | ALDH1A1 (0.55) | CYP11B1CYP11B2CHRM2CHRM3SIGMAR1 | |
| SCHEMBL13242853 | 0.77 | CYP11B1 (0.47) | CYP11B1CYP11B2CHRM2CHRM3MAOA | |
| SCHEMBL833409 | 0.77 | PRMT6 (0.68) | PRMT6SIGMAR1ALDH1A1SMN1; SMN2NCF1 | |
| Hydrochloric Acid SCHEMBL18491416 | 0.77 | ALDH1A1 (0.53) | CYP11B1CYP11B2CHRM2CHRM3MAOA | |
| SCHEMBL30469295 | 0.77 | PRMT6 (0.68) | PRMT6SIGMAR1ALDH1A1SMN1; SMN2NCF1 | |
| SCHEMBL13242846 | 0.77 | PRMT6 (0.62) | CYP11B1CYP11B2PRMT6SIGMAR1ALDH1A1 | |
| SCHEMBL12449575 | 0.76 | ALDH1A1 (0.48) | CHRM3ALDH1A1SMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3319955-B1 | 6-AMINO-QUINOLINE-3-CARBONITRILS AS COT MODULATORS | GILEAD SCIENCES INC (US) | 2020-11-25 | — | — | EP | disclosed |