Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 5/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.32 |
| ▸ | BPTF | Q12830 | 2/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24592537 | 0.80 | ALDH1A1 (0.37) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL22705177 | 0.75 | NLRP3 (0.30) | — | |
| SCHEMBL22905486 | 0.75 | ALDH1A1 (0.39) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL22705075 | 0.72 | KMT2A (0.42) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL21962721 | 0.71 | ALDH1A1 (0.41) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL9748738 | 0.70 | MAPK1 (0.45) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL22705175 | 0.69 | NLRP3 (0.39) | ALDH1A1 | |
| SCHEMBL23481706 | 0.69 | L3MBTL1 (0.38) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL22012481 | 0.69 | POLB (0.40) | ALDH1A1KDM4EKMT2AMAPTMEN1 | |
| SCHEMBL22013537 | 0.69 | MEN1 (0.54) | ALDH1A1KDM4EKMT2AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445756-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS AG (CH) | 2022-07-06 | — | — | EP | disclosed |
| EP-3445757-B1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CONDITIONS ASSOCIATED WITH NLRP ACTIVITY | NOVARTIS INFLAMMASOME RES INC (US) | 2020-11-25 | — | — | EP | disclosed |