SCHEMBL2270795

SCHEMBL2270795

CC(C)CC1C2CN(c3nc(C4=NOC(c5c(F)cccc5F)C4)cs3)CC2CN1C(=O)O

nearest known ligand 0.41

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
FAAH O00519 17/20 0.41
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
GNRHR P30968 1/20 0.32
AR P10275 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2270790 0.87 FAAH (0.42) FAAHNPC1RAB9ASMN1; SMN2AR
SCHEMBL2268188 0.78 FAAH (0.48) FAAH
SCHEMBL2222332 0.77 FAAH (0.42) FAAHNPC1RAB9ASMN1; SMN2AR
SCHEMBL2365286 0.73 FAAH (0.41) FAAH
SCHEMBL15231196 0.70 FAAH (0.45) FAAHNPC1RAB9ASMN1; SMN2AR
SCHEMBL16412321 0.70 FAAH (0.39) FAAHAR
Hydrochloric Acid SCHEMBL15231194 0.70 FAAH (0.44) FAAHNPC1RAB9ASMN1; SMN2AR
SCHEMBL15230356 0.69 FAAH (0.47) FAAH
SCHEMBL20797285 0.69 FAAH (0.61) FAAH
SCHEMBL15230625 0.69 FAAH (0.46) FAAHSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2521450-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E.I. Du Pont De Nemours And Company (US) 2012-11-14 EP disclosed
WO-2011085170-A1 FUNGICIDAL HETEROCYCLIC COMPOUNDS E. I. DU PONT DE NEMOURS AND COMPANY (US) 2011-07-14 WO disclosed