SCHEMBL15230625

SCHEMBL15230625

COC(=O)C1CN(c2nc(C3=NOC(c4c(F)cccc4F)C3)cs2)CCN1C(=O)OC(C)(C)C

nearest known ligand 0.46

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FAAH O00519 15/20 0.46
NR1H2 P55055 1/20 0.45
NR1H3 Q13133 1/20 0.45
UCHL1 P09936 1/20 0.37
USP30 Q70CQ3 2/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
MAPK1 P28482 1/20 0.36
HTT P42858 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15230574 0.82 FAAH (0.40) FAAH
SCHEMBL15230849 0.82 FAAH (0.41) FAAH
SCHEMBL2268188 0.82 FAAH (0.48) FAAHUSP30
SCHEMBL15231196 0.80 FAAH (0.45) FAAHSMN1; SMN2
Hydrochloric Acid SCHEMBL15231194 0.80 FAAH (0.44) FAAHSMN1; SMN2
SCHEMBL15230356 0.80 FAAH (0.47) FAAHUSP30
SCHEMBL21733016 0.75 FAAH (0.60) FAAH
SCHEMBL20542436 0.75 FAAH (0.60) FAAH
SCHEMBL15231469 0.74 FAAH (0.42) FAAH
SCHEMBL15231293 0.73 FAAH (0.40) FAAH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20160007606-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2016-01-14 US disclosed
EP-2820012-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES Syngenta Participations AG (CH) 2015-01-07 EP disclosed
WO-2013127784-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES SYNGENTA PARTICIPATIONS AG (CH) 2013-09-06 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20160007606-A1 MICROBIOCIDAL PYRAZOLE DERIVATIVES PRF1, CASP1, MPO FAAH 788/4885NR1H2 1229/4885NR1H3 1600/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.