Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IP6K1 | Q92551 | 5/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.39 |
| ▸ | PARP1 | P09874 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30681131 | 0.85 | IP6K1 (0.49) | IP6K1CRBNPARP1BACE1 | |
| SCHEMBL29930715 | 0.85 | IP6K1 (0.49) | IP6K1CRBNPARP1BACE1 | |
| SCHEMBL20066150 | 0.79 | MEN1 (0.35) | IP6K1CRBN | |
| SCHEMBL23778395 | 0.76 | MEN1 (0.36) | IP6K1 | |
| SCHEMBL22711766 | 0.75 | IP6K1 (0.38) | IP6K1BACE1 | |
| SCHEMBL30681138 | 0.75 | IP6K1 (0.38) | IP6K1BACE1 | |
| SCHEMBL22711790 | 0.74 | PDE4A (0.36) | IP6K1 | |
| SCHEMBL22711811 | 0.73 | IP6K1 (0.56) | IP6K1CRBNMAPK1 | |
| SCHEMBL30681102 | 0.72 | IP6K1 (0.44) | IP6K1CRBNPARP1BACE1 | |
| SCHEMBL28728372 | 0.70 | MAPK14 (0.40) | IP6K1CRBNPARP1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250346572-A1 | NON-ACID INHIBITORS OF INOSITOL HEXAKISPHOSPHATE KINASE (IP6K) AND METHODS OF USE THEREOF | LIEBER INST INC (US) | 2025-11-13 | — | — | US | disclosed |
| EP-4539838-A1 | NON-ACID INHIBITORS OF INOSITOL HEXAKISPHOSPHATE KINASE (IP6K) AND METHODS OF USE THEREOF | Lieber Institute, Inc. (US) | 2025-04-23 | — | — | EP | disclosed |
| WO-2023244657-A1 | NON-ACID INHIBITORS OF INOSITOL HEXAKISPHOSPHATE KINASE (IP6K) AND METHODS OF USE THEREOF | LIEBER INSTITUTE, INC. (US) | 2023-12-21 | — | — | WO | disclosed |
| US-10968178-B2 | IP6K inhibitors | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2021-04-06 | — | — | US | disclosed |
| US-20200377458-A1 | IP6K INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250346572-A1 | NON-ACID INHIBITORS OF INOSITOL HEXAKISPHOSPHATE KINASE (IP6K) AND METHODS OF USE THEREOF | IP6K1, IP6K2, IP6K3 | IP6K1 1/4885CRBN 4013/4885PARP1 3840/4885 |
| US-20200377458-A1 | IP6K INHIBITORS | IP6K1, IP6K2, IP6K3 | IP6K1 1/4885CRBN 3683/4885PARP1 4130/4885 |
| US-10968178-B2 | IP6K inhibitors | IP6K1, IP6K2, IP6K3 | IP6K1 1/4885CRBN 3683/4885PARP1 4130/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.