IP6K2

Inositol hexakisphosphate kinase 2 · Q9UHH9 · IP6K2 on Sugi Atlas →

9,383 patent compounds predicted against IP6K2, 6,716 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Tamarixetin (SCHEMBL892776)	0.82	6/20
Quercetin (SCHEMBL1545849)	0.72	6/20
Apigenin (SCHEMBL19428)	1.00	5/20
Quercetin (SCHEMBL19723)	1.00	5/20
Quercetin (SCHEMBL118425)	1.00	5/20
Diosmetin (SCHEMBL289337)	1.00	5/20
Quercetin (SCHEMBL22103)	0.97	5/20
Quercetin (SCHEMBL1658852)	0.97	5/20
Apigenin (SCHEMBL1655606)	0.97	5/20
Apigenin (SCHEMBL1658882)	0.97	5/20
Quercetin (SCHEMBL288466)	0.92	5/20
Myricetin (SCHEMBL1064954)	0.92	5/20
Quercetin (SCHEMBL1148195)	0.90	5/20
Chrysoeriol (SCHEMBL293757)	0.81	5/20
SCHEMBL491032	0.77	5/20
Quercetin (SCHEMBL729498)	0.76	5/20
Kaempferide (SCHEMBL426774)	0.75	5/20
Tricin (SCHEMBL44475)	0.73	5/20
SCHEMBL360758	0.72	5/20
Quercetin (SCHEMBL117829)	0.72	5/20

Clinical trials — most relevant to IP6K2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
The Effect of the Preoperative Oral Carbohydrate Attenuating Immediate Postoperative Insulin Resistance on PI3K Dependent Signaling Pathway	PHASE4	COMPLETED
Effect of a Basal/Pre-Meal Insulin Strategy (Detemir/Aspart) on Insulin Secretion and Action in Type 2 Diabetes	PHASE4	COMPLETED
Short-Term Metformin Use in Young, Healthy Adults: Impacts on Exercise Capacity	PHASE4	COMPLETED
The G Protein-Coupled Receptor Kinase Type 2 Inhibitor Paroxetine as Adjunctive Therapy to Improve Insulin Sensitivity in Patients With Type 2 Diabetes Mellitus	PHASE3	UNKNOWN
Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients	PHASE3	COMPLETED
Mitochondrial Oxidation and Insulin Resistance in Burn Patients Treated With Fenofibrate	PHASE2/PHASE3	WITHDRAWN
Ursodeoxycholic Acid as add-on Therapy in Type 2 Diabetes Mellitus	PHASE2/PHASE3	UNKNOWN
HP-211 Safety and Proof of Concept Dose Ranging Study in Patients With Type 2 Diabetes	PHASE2	RECRUITING
Biological Effects of Quercetin in COPD Phase II	PHASE2	UNKNOWN
Biological Effects of Quercetin in COPD	PHASE1/PHASE2	UNKNOWN
Analysis of Tissues From Patients in Trial of Myo-Inositol to Prevent Lung Cancer	PHASE1	COMPLETED
Acute Effect of HP-211 (Axulin) on Blood Glucose and Serum Insulin Responses in Healthy Lean and Overweight Humans	PHASE1	COMPLETED
Temsirolimus and Sorafenib in Advanced Hepatocellular Carcinoma	PHASE1	COMPLETED
Pre-Surgical Trial of the Combination of Metformin and Atorvastatin in Newly Diagnosed Operable Breast Cancer	EARLY_PHASE1	COMPLETED
Duality of Lipids: the Athlete's Paradox	nan	COMPLETED
Evaluation of Plasma Sphingosine-1-Phosphate as A Diagnostic and Prognostic Biomarkers of Community-Acquired Pneumonia	nan	UNKNOWN
The Study Aims to Investigate the Effects of Oral Inositols on Insulin-resistance in Children With Obesity.	nan	UNKNOWN
The Effect Of DAAs on miRNA-122 And Insulin Resistance In Chronic HCV Patients	nan	UNKNOWN
Defective Atypical Protein Kinase C (PKC) Activation in Diabetes and Metabolic Syndrome	nan	COMPLETED
Dried Fruit and Postprandial Glycemia Trial	nan	UNKNOWN
Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia	nan	RECRUITING
Effect of Short-Term Exercise Training on ATP Synthesis in Relatives of Type 2 Diabetic Humans	nan	COMPLETED
Vulvodynia: Identification of Potential Relevant Biomarkers	nan	COMPLETED
p-AKT Expression on Clinical Outcomes in Malignant Lymphoma	nan	COMPLETED
Metabolic Signalling in Muscle- and Adipose-tissue Following Insulin Withdrawal and Growth Hormone Injection.	nan	COMPLETED
Free Fatty Acid Induced Insulin Resistance	nan	COMPLETED
Genetic Variation in TRAF3IP2 (rs13190932)	nan	RECRUITING
Dietary Ketosis: Fatty Acids Activate AMPK Energy Circuits Modulating Global Methylation	nan	COMPLETED
Novel Therapy for Glucose Intolerance in HIV Disease	nan	COMPLETED
Myoinositol Treatment and Asprosin Levels in PCOS	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a IP6K2 binder may also engage these)

Protein	Name	Similarity
Q9R0U1	—	1.000	Q9R0U1 →
Q95221	—	0.998	Q95221 →
Q80V72	—	0.995	Q80V72 →
Q8BWD2	—	0.983	Q8BWD2 →
Q99NI4	—	0.982	Q99NI4 →
Q7TT16	—	0.977	Q7TT16 →
IPMK	Inositol polyphosphate multikinase	0.975	landscape →
IP6K3	Inositol hexakisphosphate kinase 3	0.973	landscape →
Q80XI4	—	0.963	Q80XI4 →
O88377	—	0.963	O88377 →
PIP4K2B	Phosphatidylinositol 5-phosphate 4-kinase type-2 beta	0.961	landscape →
Q5PQ01	—	0.960	Q5PQ01 →
O13010	—	0.958	O13010 →
PIP4K2A	Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha	0.958	landscape →
Q6IQE1	—	0.958	Q6IQE1 →
A4IID4	—	0.957	A4IID4 →
O02810	—	0.957	O02810 →
Q8BHD4	—	0.957	Q8BHD4 →
PI4KB	Phosphatidylinositol 4-kinase beta	0.956	landscape →
E9Q4Z2	—	0.956	E9Q4Z2 →
Q5R488	—	0.955	Q5R488 →
Q5R803	—	0.955	Q5R803 →
Q9R0I8	—	0.955	Q9R0I8 →
B4UT09	—	0.954	B4UT09 →
O88370	—	0.954	O88370 →
B0KWC1	—	0.954	B0KWC1 →
B1MTG7	—	0.954	B1MTG7 →
Q7TPQ3	—	0.954	Q7TPQ3 →
B2KI64	—	0.953	B2KI64 →
O08561	—	0.953	O08561 →