Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.44 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | FOXO3 | O43524 | 1/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.44 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.44 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.44 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.44 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.44 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.44 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21001991 | 1.00 | ALDH1A1 (0.44) | ALDH1A1TP53SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL21001970 | 0.83 | LMNA (0.50) | ALDH1A1TP53SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL22713063 | 0.83 | LMNA (0.50) | ALDH1A1TP53SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL20519313 | 0.79 | NPC1 (0.43) | ALDH1A1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL20524397 | 0.79 | NPC1 (0.43) | ALDH1A1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL21001906 | 0.76 | SMN1; SMN2 (0.57) | ALDH1A1TP53SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL21002518 | 0.76 | SMN1; SMN2 (0.57) | ALDH1A1TP53SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL21041290 | 0.76 | ALDH1A1 (0.41) | ALDH1A1TP53SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL21334944 | 0.75 | KDM5B (0.37) | ALDH1A1SMN1; SMN2LMNANPC1RAB9A | |
| SCHEMBL21334896 | 0.74 | NPC1 (0.49) | ALDH1A1LMNANPC1CYP3A4RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11485725-B2 | Derivatives of piperlongumine and uses thereof | AURANSA INC. (US) | 2022-11-01 | — | — | US | disclosed |
| US-20210198235-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. | 2021-07-01 | — | — | US | disclosed |
| US-20200377510-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | AURANSA INC. | 2020-12-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200377510-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | SHARPIN, PIR, THPO | ALDH1A1 421/4885TP53 1020/4885SMN1; SMN2 4475/4885 |
| US-20210198235-A1 | DERIVATIVES OF PIPERLONGUMINE AND USES THEREOF | THPO, PIR, PAK6 | ALDH1A1 228/4885TP53 148/4885SMN1; SMN2 4277/4885 |
| US-11485725-B2 | Derivatives of piperlongumine and uses thereof | PIR, THPO, DHPS | ALDH1A1 251/4885TP53 172/4885SMN1; SMN2 4366/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.