Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.33 |
| ▸ | HPGD | P15428 | 3/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | SI | P14410 | 1/20 | 0.33 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26599304 | 0.81 | CYP3A4 (0.52) | CYP3A4CYP19A1MGAMGAASI | |
| SCHEMBL22717648 | 0.78 | RAB9A (0.43) | MBOAT4CYP3A4ALDH1A1HPGDMGAM | |
| SCHEMBL22717489 | 0.78 | ALDH1A1 (0.43) | ALDH1A1KDM4EHPGDNPC1TP53 | |
| SCHEMBL22717514 | 0.78 | MEN1 (0.41) | MBOAT4ALDH1A1KDM4EHTTMGAM | |
| SCHEMBL29108375 | 0.78 | KDM4E (0.33) | MBOAT4ALDH1A1KDM4EHPGDNPC1 | |
| SCHEMBL29574403 | 0.77 | FFAR4 (0.35) | ALDH1A1HPGD | |
| SCHEMBL22717605 | 0.77 | FFAR4 (0.35) | ALDH1A1HPGD | |
| SCHEMBL29695046 | 0.76 | ALDH1A1 (0.46) | MBOAT4ALDH1A1KDM4EHPGDL3MBTL1 | |
| SCHEMBL29108435 | 0.76 | PIK3CA (0.36) | ALDH1A1KDM4EHPGDL3MBTL1MGAM | |
| SCHEMBL29108351 | 0.76 | ALDH1A1 (0.46) | MBOAT4ALDH1A1KDM4EHPGDL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118974043-A | Polq inhibitor compounds and uses thereof | 南京再明医药有限公司 | 2024-11-15 | — | — | CN | disclosed |
| EP-3976608-B1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2023202623-A1 | POLQ INHIBITOR COMPOUND AND USE THEREOF | 南京再明医药有限公司 | 2023-10-26 | — | — | WO | disclosed |
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |