Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 7/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.31 |
| ▸ | PI4KA | P42356 | 1/20 | 0.31 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.30 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.30 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.30 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.30 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.30 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29108432 | 0.85 | MBOAT4 (0.32) | MBOAT4 | |
| SCHEMBL29694668 | 0.85 | MBOAT4 (0.32) | MBOAT4 | |
| SCHEMBL22717603 | 0.82 | MGAM (0.40) | — | |
| SCHEMBL22717489 | 0.77 | ALDH1A1 (0.43) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB | |
| SCHEMBL22717648 | 0.77 | RAB9A (0.43) | MBOAT4PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL22717514 | 0.77 | MEN1 (0.41) | MBOAT4PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL29694658 | 0.76 | MBOAT4 (0.39) | MBOAT4 | |
| SCHEMBL29108267 | 0.76 | MBOAT4 (0.39) | MBOAT4 | |
| SCHEMBL29108351 | 0.75 | ALDH1A1 (0.46) | MBOAT4PIK3CDPIK3CAPIK3CBPI4KA | |
| SCHEMBL29108435 | 0.75 | PIK3CA (0.36) | PIK3CDPIK3CAPIK3CBPI4KAPI4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3976608-B1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES INC (US) | 2023-11-08 | — | — | EP | disclosed |
| EP-3976608-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | Ideaya Biosciences, Inc. (US) | 2022-04-06 | — | — | EP | disclosed |
| CN-114127062-A | Thiadiazolyl derivatives as inhibitors of DNA polymerase Theta | 伊迪亚生物科学有限公司 | 2022-03-01 | — | — | CN | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |
| WO-2020243459-A1 | THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS | IDEAYA BIOSCIENCES, INC. (US) | 2020-12-03 | — | — | WO | disclosed |